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Pathogens Associated With Linear Growth Faltering in Children With Diarrhea and Impact of Antibiotic Treatment: The Global Enteric Multicenter Study

2021; Oxford University Press; Volume: 224; Issue: Supplement_7 Linguagem: Inglês

10.1093/infdis/jiab434

1537-6613

Dilruba Nasrin, William C. Blackwelder, Halvor Sommerfelt, Yukun Wu, Tamer H. Farag, Sandra Panchalingam, Kousick Biswas, Debasish Saha, M Jahangir Hossain, Samba O. Sow, Robert F B Reiman, Dipika Sur, Abu Syed Golam Faruque, Anita K. M. Zaidi, Doh Sanogo, Boubou Tamboura, Uma Onwuchekwa, Byomkesh Manna, Thandavarayan Ramamurthy, Suman Kanungo, Richard Omore, John B. Ochieng, Joseph Oundo, Sumon K. Das, Shahnawaz Ahmed, Shahida Qureshi, Farheen Quadri, Richard A. Adegbola, Martín Antonio, Inácio Mandomando, Tacilta Nhampossa, Quique Bassat, Anna Roose, Ciara E. O’Reilly, Eric D. Mintz, Usha Ramakrishnan, Helen Powell, Yuanyuan Liang, James P. Nataro, Myron M. Levine, Karen L. Kotloff,

Clostridium difficile and Clostridium perfringens research

The association between childhood diarrheal disease and linear growth faltering in developing countries is well described. However, the impact attributed to specific pathogens has not been elucidated, nor has the impact of recommended antibiotic treatment.The Global Enteric Multicenter Study enrolled children with moderate to severe diarrhea (MSD) seeking healthcare at 7 sites in sub-Saharan Africa and South Asia. At enrollment, we collected stool samples to identify enteropathogens. Length/height was measured at enrollment and follow-up, approximately 60 days later, to calculate change in height-for-age z scores (ΔHAZ). The association of pathogens with ΔHAZ was tested using linear mixed effects regression models.Among 8077 MSD cases analyzed, the proportion with stunting (HAZ below -1) increased from 59% at enrollment to 65% at follow-up (P < .0001). Pathogens significantly associated with linear growth decline included Cryptosporidium (P < .001), typical enteropathogenic Escherichia coli (P = .01), and untreated Shigella (P = .009) among infants (aged 0-11 months) and enterotoxigenic E. coli encoding heat-stable toxin (P < .001) and Cryptosporidium (P = .03) among toddlers (aged 12-23 months). Shigella-infected toddlers given antibiotics had improved linear growth (P = .02).Linear growth faltering among children aged 0-23 months with MSD is associated with specific pathogens and can be mitigated with targeted treatment strategies, as demonstrated for Shigella.