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The ongoing evolution of variants of concern and interest of SARS-CoV-2 in Brazil revealed by convergent indels in the amino (N)-terminal domain of the spike protein

2021; University of Oxford; Volume: 7; Issue: 2 Linguagem: Inglês

10.1093/ve/veab069

2057-1577

Paola Cristina Resende, Felipe Gomes Naveca, Roberto D. Lins, Filipe Zimmer Dezordi, Matheus Ferraz, Emerson G. Moreira, Danilo F. Côelho, Fernando Couto Motta, Anna Carolina Dias Paixão, Luciana Appolinario, Renata Serrano Lopes, Ana Carolina da Fonseca Mendonça, Alice Sampaio Barreto da Rocha, Valdinete Alves do Nascimento, Victor Costa de Souza, George Silva, Fernanda Nascimento, Lídio Gonçãlves Lima Neto, Fabiano Vieira da Silva, Irina Nastassja Riediger, Maria do Carmo Debur, Anderson Brandão Leite, Tirza Mattos, Cristiano Fernandes da Costa, Felicidade Mota Pereira, Cliomar Alves dos Santos, Darcita Büerger Rovaris, Sandra Bianchini Fernandes, Adriano Abbud, Cláudio Tavares Sacchi, Ricardo Khouri, André Felipe Leal Bernardes, Edson Delatorre, Tiago Gräf, Marilda Mendonça Siqueira, Gonzalo Bello, Gabriel Luz Wallau,

SARS-CoV-2 detection and testing

Mutations at both the receptor-binding domain (RBD) and the amino (N)-terminal domain (NTD) of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike (S) glycoprotein can alter its antigenicity and promote immune escape. We identified that SARS-CoV-2 lineages circulating in Brazil with mutations of concern in the RBD independently acquired convergent deletions and insertions in the NTD of the S protein, which altered the NTD antigenic-supersite and other predicted epitopes at this region. Importantly, we detected the community transmission of different P.1 lineages bearing NTD indels ∆69-70 (which can impact several SARS-CoV-2 diagnostic protocols), ∆144 and ins214ANRN, and a new VOI N.10 derived from the B.1.1.33 lineage carrying three NTD deletions (∆141-144, ∆211, and ∆256-258). These findings support that the ongoing widespread transmission of SARS-CoV-2 in Brazil generates new viral lineages that might be more resistant to antibody neutralization than parental variants of concern.