Synapsin-Promoted Caveolin-1 Overexpression Maintains Mitochondrial Morphology and Function in PSAPP Alzheimer’s Disease Mice
2021; Multidisciplinary Digital Publishing Institute; Volume: 10; Issue: 9 Linguagem: Inglês
10.3390/cells10092487
ISSN2073-4409
AutoresShanshan Wang, Taiga Ichinomiya, Yuki Terada, Dongsheng Wang, Hemal H. Patel, Brian P. Head,
Tópico(s)Alzheimer's disease research and treatments
ResumoMitochondrial dysfunction plays a pivotal role in the Alzheimer's Disease (AD) pathology. Disrupted mitochondrial dynamics (i.e., fusion/fission balance), which are essential for normal mitochondria structure and function, are documented in AD. Caveolin-1 (Cav-1), a membrane/lipid raft (MLR) scaffolding protein regulates metabolic pathways in several different cell types such as hepatocytes and cancer cells. Previously, we have shown decreased expression of Cav-1 in the hippocampus of 9-month (m) old PSAPP mice, while hippocampal overexpression of neuron-targeted Cav-1 using the synapsin promoter (i.e.,
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