Portal de Periódicos da CAPES

COVID-19 Infection in Pregnancy: PCR Cycle Thresholds, Placental Pathology, and Perinatal Outcomes

2021; Multidisciplinary Digital Publishing Institute; Volume: 13; Issue: 9 Linguagem: Inglês

10.3390/v13091884

1999-4915

Estibalitz Laresgoiti‐Servitje, Jorge Arturo Cardona–Pérez, Rosa Gabriela Hernández-Cruz, Addy Cecilia Helguera‐Repetto, María Yolotzin Valdespino-Vázquez, Elsa Romelia Moreno‐Verduzco, Isabel Villegas‐Mota, Sandra Acevedo‐Gallegos, Mario Rodríguez‐Bosch, Moisés León‐Juárez, Mónica Aguinaga‐Ríos, I.A. Coronado-Zarco, A. Ortiz‐Calvillo, María Antonieta Rivera-Rueda, Carolina Valencia-Contreras, María de Lourdes Gómez-Sousa, Juan Mario Solis-Paredes, Juan Carlos Rodríguez‐Aldama, Rafael Galván-Contreras, Ricardo Figueroa-Damián, Manuel Cortés‐Bonilla, Guadalupe Estrada‐Gutiérrez, Salvador Espino y Sosa, Claudine Irles,

Pregnancy and Medication Impact

(1) This study aimed to evaluate characteristics, perinatal outcomes, and placental pathology of pregnant women with or without SARS-CoV-2 infection in the context of maternal PCR cycle threshold (CT) values. (2) This was a retrospective case-control study in a third-level health center in Mexico City with universal screening by RT-qPCR. The association of COVID-19 manifestations, preeclampsia, and preterm birth with maternal variables and CT values were assessed by logistic regression models and decision trees. (3) Accordingly, 828 and 298 women had a negative and positive test, respectively. Of those positive, only 2.6% of them presented mild to moderate symptoms. Clinical characteristics between both groups of women were similar. No associations between CT values were found for maternal features, such as pre-gestational BMI, age, and symptomatology. A significantly higher percentage of placental fibrinoid was seen with women with low CTs (<25; p < 0.01). Regarding perinatal outcomes, preeclampsia was found to be significantly associated with symptomatology but not with risk factors or CT values (p < 0.01, aOR = 14.72). Moreover, 88.9% of women diagnosed with COVID-19 at <35 gestational weeks and symptomatic developed preeclampsia. (4) The data support strong guidance for pregnancies with SARS-CoV-2 infection, in particular preeclampsia and placental pathology, which need further investigation.