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Relationships between frontal metabolites and Alzheimer's disease biomarkers in cognitively normal older adults

2021; Elsevier BV; Volume: 109; Linguagem: Inglês

10.1016/j.neurobiolaging.2021.09.016

1558-1497

Antoine Hone‐Blanchet, Anastasia Bohsali, Lisa C. Krishnamurthy, Syed Salman Shahid, Qixiang Lin, Liping Zhao, David W. Loring, Felicia C. Goldstein, Samantha E. John, Candace C. Fleischer, Allan I. Levey, James J. Lah, Deqiang Qiu, Bruce Crosson,

Metabolomics and Mass Spectrometry Studies

Elevated expression of β-amyloid (Aβ1-42) and tau are considered risk-factors for Alzheimer's disease in healthy older adults. We investigated the effect of aging and cerebrospinal fluid levels of Aβ1-42 and tau on 1) frontal metabolites measured with proton magnetic resonance spectroscopy (MRS) and 2) cognition in cognitively normal older adults (n = 144; age range 50-85). Levels of frontal gamma aminobutyric acid (GABA+) and myo-inositol relative to creatine (mI/tCr) were predicted by age. Levels of GABA+ predicted cognitive performance better than mI/tCr. Additionally, we found that frontal levels of n-acetylaspartate relative to creatine (tNAA/tCr) were predicted by levels of t-tau. In cognitively normal older adults, levels of frontal GABA+ and mI/tCr are predicted by aging, with levels of GABA+ decreasing with age and the opposite for mI/tCr. These results suggest that age- and biomarker-related changes in brain metabolites are not only located in the posterior cortex as suggested by previous studies and further demonstrate that MRS is a viable tool in the study of aging and biomarkers associated with pathological aging and Alzheimer's disease.