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Low-Level Viremia Is Associated With Cumulative Adherence to Antiretroviral Therapy in Persons With HIV

2021; Oxford University Press; Volume: 8; Issue: 9 Linguagem: Inglês

10.1093/ofid/ofab463

2328-8957

José Castillo‐Mancilla, Mary Morrow, Ryan P. Coyle, Stacey S. Coleman, Jia‐Hua Zheng, Lucas Ellison, Lane R. Bushman, Jennifer J. Kiser, Peter L. Anderson, Samantha MaWhinney,

HIV/AIDS drug development and treatment

The drivers of low-level viremia (LLV) between 20 and 200 copies/mL remain unclear. In 1042 person-visits from 497 persons with HIV on tenofovir disoproxil fumarate-containing antiretroviral therapy (ART), the association between LLV and cumulative antiretroviral adherence (quantified using tenofovir diphosphate [TFV-DP] in dried blood spots) was assessed. Lower TFV-DP levels were associated with higher odds of LLV. As TFV-DP (fmol/punch) categories decreased from >1650 to 800-1650; 800-1650 to 1650 to <800, the adjusted odds ratios for LLV vs HIV VL <20 copies/mL were 2.0 (95% CI, 1.2-3.1), 2.4 (95% CI, 1.1-5.0), and 4.6 (95% CI, 2.2-9.9), respectively. This suggests that adherence could impact LLV.