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Cytotoxicity evaluation and DNA interaction of Ru II -bipy complexes containing coumarin-based ligands

2021; Royal Society of Chemistry; Volume: 50; Issue: 41 Linguagem: Inglês

10.1039/d1dt01567b

1477-9234

Patrícia S.V.B. de Almeida, Henrique Jefferson de Arruda, Gleyton Leonel Silva Sousa, Felipe Vitório Ribeiro, José Aleixo de Azevedo-França, Larissa A. Ferreira, Guilherme P. Guedes, Heveline Silva, Arthur Eugen Kümmerle, Amanda P. Neves,

Synthesis and Characterization of Heterocyclic Compounds

Cationic Ru II complexes derived from coumarin hybrids and bipyridine have shown greater cytotoxicity than the free ligands. Our findings have been associated to the strongest ability of the complexes to interact with DNA.