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Verbal and General IQ Associate with Supragranular Layer Thickness and Cell Properties of the Left Temporal Cortex

2021; Oxford University Press; Volume: 32; Issue: 11 Linguagem: Inglês

10.1093/cercor/bhab330

1460-2199

Djai B. Heyer, René Wilbers, Anna A. Galakhova, Els Hartsema, S. Braak, Sarah Hunt, Matthijs B Verhoog, M L Muijtjens, Eline J. Mertens, Sander Idema, Johannes C. Baayen, Philip de Witt Hamer, Martin Klein, Mary McGraw, Ed S. Lein, Christiaan P. J. de Kock, Huibert D. Mansvelder, Natalia A. Goriounova,

Reading and Literacy Development

Abstract The left temporal lobe is an integral part of the language system and its cortical structure and function associate with general intelligence. However, whether cortical laminar architecture and cellular properties of this brain area relate to verbal intelligence is unknown. Here, we addressed this using histological analysis and cellular recordings of neurosurgically resected temporal cortex in combination with presurgical IQ scores. We find that subjects with higher general and verbal IQ scores have thicker left (but not right) temporal cortex (Brodmann area 21, BA21). The increased thickness is due to the selective increase in layers 2 and 3 thickness, accompanied by lower neuron densities, and larger dendrites and cell body size of pyramidal neurons in these layers. Furthermore, these neurons sustain faster action potential kinetics, which improves information processing. Our results indicate that verbal mental ability associates with selective adaptations of supragranular layers and their cellular micro-architecture and function in left, but not right temporal cortex.