Produção Nacional
Revisado por pares
Electromyography in Congenital Zika Syndrome
2021; Lippincott Williams & Wilkins; Volume: 40; Issue: 4 Linguagem: Inglês
10.1097/wnp.0000000000000893
ISSN1537-1603
AutoresAna Cláudia Marques Gouveia de Melo, Vanessa van der Linden, Sarah Costa Serpa, Epitácio Leite Rolim Filho, Otávio Gomes Lins,
Tópico(s)Virology and Viral Diseases
ResumoCongenital Zika virus syndrome is a distinct pattern of birth defects in fetuses infected by the Zika virus. It presents a broad clinical spectrum that includes occurrences of microcephaly, hypertonia, dysphagia, hyperexcitability, seizures, and arthrogryposis. Imaging findings show neuronal migration disorders.Case reports have suggested that arthrogryposis has a neurogenic cause. We analyzed needle electromyography and nerve conduction examinations on 77 patients aged 2-24 months presenting highly probable congenital Zika virus syndrome, with or without arthrogryposis.All those with arthrogryposis presented with chronic muscle denervation in the electromyography examination. Similarly, children with single or reversible joint abnormalities at birth showed the same findings. Denervation in the paravertebral musculature was found in all of the children with diaphragmatic paralysis or thoracic deformities.We propose that congenital contractures associated with congenital Zika virus syndrome are caused by the malformation of upper and lower motor neurons during embryogenesis.
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