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In Utero Exposure to Persistent Organic Pollutants and Childhood Lipid Levels

2021; Multidisciplinary Digital Publishing Institute; Volume: 11; Issue: 10 Linguagem: Inglês

10.3390/metabo11100657

2218-1989

Maegan E. Boutot, Brian W. Whitcomb, Nadia Abdelouahab, Andrea Baccarelli, Amélie Boivin, Artuela Çaku, Virginie Gillet, Guillaume Martinez, Jean‐Charles Pasquier, Jiping Zhu, Larissa Takser, Lindsay St-Cyr, Alexander Suvorov,

Birth, Development, and Health

Animal studies have shown that developmental exposures to polybrominated diphenyl ethers (PBDE) permanently affect blood/liver balance of lipids. No human study has evaluated associations between in utero exposures to persistent organic pollutants (POPs) and later life lipid metabolism. In this pilot, maternal plasma levels of PBDEs (BDE-47, BDE-99, BDE-100, and BDE-153) and polychlorinated biphenyls (PCB-138, PCB-153, and PCB-180) were determined at delivery in participants of GESTation and Environment (GESTE) cohort. Total cholesterol (TCh), triglycerides (TG), low- and high-density lipoproteins (LDL-C and HDL-C), total lipids (TL), and PBDEs were determined in serum of 147 children at ages 6-7. General linear regression was used to estimate the relationship between maternal POPs and child lipid levels with adjustment for potential confounders, and adjustment for childhood POPs. In utero BDE-99 was associated with lower childhood levels of TG (