Artigo Acesso aberto Revisado por pares

CPEB alteration and aberrant transcriptome-polyadenylation lead to a treatable SLC19A3 deficiency in Huntington’s disease

2021; American Association for the Advancement of Science; Volume: 13; Issue: 613 Linguagem: Inglês

10.1126/scitranslmed.abe7104

ISSN

1946-6242

Autores

Sara Picó, Alberto Parras, María Santos‐Galindo, Julia Pose‐Utrilla, Margarita Castro, Enrique Fraga, Ivó H. Hernández, Ainara Elorza, Héctor Anta, Nan Wang, Laura Martí‐Sánchez, Eulàlia Belloc, Paula Garcia‐Esparcia, Juan José Garrido, Isidró Ferrer, Daniel Macías‐García, Pablo Mir, Rafael Artuch, Belén Pérez, Félix Hernández, Pilar Navarro, José Luis López-Sendón, Teresa Iglesias, Xia Yang, Raúl Méndez, José J. Lucas,

Tópico(s)

Parkinson's Disease Mechanisms and Treatments

Resumo

Altered CPEBs and mRNA polyadenylation lead to thiamine deficiency in the brains of patients and mice with Huntington’s disease.

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