Apigenin: A methanol fraction component of Newbouldia laevis leaf, as a potential antidiabetic agent
2017; Volume: 6; Issue: 1 Linguagem: Inglês
10.31254/phyto.2017.6106
ISSN2320-480X
AutoresChinyelu Clementina Osigwe, Peter A. Akah, Chukwuemeka S. Nworu, Festus Basden Chiedu Okoye,
Tópico(s)Diabetes, Cardiovascular Risks, and Lipoproteins
ResumoThe leaves of Newbouldia laevis is traditionally used to treat diabetes mellitus in southeast Nigeria. The apigenin isolated from the methanol fraction of dichloromethane/methanol (1:1) extract of the leaves was evaluated for antidiabetic and antihyperglycemic activity in alloxan-induced diabetic rats and on normal rats. Treatment of alloxan-diabetic rats with the compound (apigenin) significantly (p < 0.05) reduced blood glucose, and increased the liver and muscle glycogen content. The adrenaline-induced elevation of blood glucose of normal rats was significantly (p < 0.05) reduced by the isolated compound. These results suggest that apigenin may be the anti-diabetic principle in the leaves of Newbouldia laevis..
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