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Novel alphaherpesvirus in a wild South American sea lion (Otaria byronia) with pulmonary tuberculosis

2021; Springer Nature; Volume: 52; Issue: 4 Linguagem: Inglês

10.1007/s42770-021-00614-z

1678-4405

Carlos Sacristán, Samira Costa‐Silva, Laura Reisfeld, Pedro Enrique Navas‐Suárez, Ana Carolina Ewbank, Arícia Duarte-Benvenuto, Natália Coelho Couto de Azevedo Fernandes, Rodrigo Albergaria Réssio, Marzia Antonelli, Janaina Rocha Lorenço, Cíntia Maria Favero, Juliana Marigo, Cristiane K. M. Kolesnikovas, José Luiz Catão‐Dias,

Immune Response and Inflammation

In 2017, an adult male South American sea lion (Otaria byronia), presenting emaciation and a cervical abscess, stranded alive in Florianópolis, southern Brazil. The animal was directed to a rehabilitation center, dying a few days later. On necropsy, the main gross findings were necrotizing lymphadenitis of the right prescapular lymph node and nodular bronchopneumonia. A novel alphaherpesvirus, tentatively named Otariid alphaherpesvirus 1, was amplified in several tissue samples. No histopathologic findings associated with viral infection were observed. Additionally, pulmonary tuberculosis by Mycobacterium pinnipedii was diagnosed by histopathological, immunohistochemical, and molecular techniques. Several bacteria were cultured from antemortem and postmortem samples, including Proteus mirabilis from the cervical abscess and cardiac blood, and Escherichia coli from the cervical abscess and pericardial effusion. Flavivirus, morbillivirus, and Apicomplexa were not detected by molecular techniques. Herein, we report a novel alphaherpesvirus in a pinniped species of the family Otariidae. Although previously described in Southern Hemisphere pinniped species, including South American sea lions, there is limited information regarding M. pinnipedii impact over this group. Further research is required to determine the associated pathogenesis of this novel herpesvirus, and prevalence of Otariid alphaherpesvirus 1 and M. pinnipedii in the reproductive colonies.