National Cancer Institute Intramural Research on Human Immunodeficiency Virus Inhibitory and Antitumor Plant Natural Products
1993; American Chemical Society; Linguagem: Inglês
10.1021/bk-1993-0534.ch015
ISSN1947-5918
AutoresJohn H. Cardellina, Kirk R. Gustafson, John A. Beutler, Tawnya C. McKee, Yali F. Hallock, Richard W. Fuller, Michael R. Boyd,
Tópico(s)Natural product bioactivities and synthesis
ResumoThe natural products drug discovery program of the United States National Cancer Institute (NCI) was dramatically reorganized and revitalized during the mid-to-late 1980's. One component of the overall strategic approach was the creation of the first-ever intramural, interdisciplinary research unit, the Laboratory of Drug Discovery Research and Development (LDDRD), with a central focus on natural products. LDDRD scientists identify leads from extracts housed in the NCI Natural Products Repository and screened in the high throughput in vitro antitumor and AIDS-antiviral bioassays, isolate and identify the antitumor and/or antiviral agents through bioassay-guided fractionation and spectral analyses, and examine in detail the biological activity of the isolated compounds. This report focuses on some selected illustrative examples of LDDRD research on HIV-inhibitory and antitumor plant natural products.
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