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2020 WHO Classification of Female Genital Tumors

2021; Thieme Medical Publishers (Germany); Volume: 81; Issue: 10 Linguagem: Inglês

10.1055/a-1545-4279

2199-6989

Anne Kathrin Höhn, Christine E. Brambs, Grit Gesine Ruth Hiller, Doris May, Elisa Schmoeckel, Lars‐Christian Horn,

Endometrial and Cervical Cancer Treatments

Abstract The 2020 WHO classification is focused on the distinction between HPV-associated and HPV-independent squamous cell carcinoma of the lower female genital organs. Differentiating according to HPV association does not replace the process of grading; however, the WHO classification does not recommend any specific grading system. VIN are also differentiated according to whether they are HPV(p16)-associated. HPV-independent adenocarcinoma (AC) of the cervix uteri has an unfavorable prognosis. Immunohistochemical p16 expression is considered to be a surrogate marker for HPV association. HPV-associated AC of the cervix uteri is determined using the prognostically relevant Silva pattern.