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A Patent Review on SARS Coronavirus Main Protease (3CL pro ) Inhibitors

2021; Wiley; Volume: 17; Issue: 1 Linguagem: Inglês

10.1002/cmdc.202100576

1860-7187

C. S. Brian Chia, Weijun Xu, Pearly Shuyi Ng,

Synthesis and biological activity

Abstract The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic is an unprecedented global health emergency causing more than 4.2 million fatalities as of 30 July 2021. Only three antiviral therapies have been approved or granted emergency use authorization by the FDA. The SARS‐CoV‐2 3CL protease (3CL pro ) is deemed an attractive drug target as it plays an essential role in viral polyprotein processing and pathogenesis, although no inhibitors have been approved. This patent review discusses SARS coronavirus 3CL pro inhibitors that have been filed up to 30 July 2021, giving an overview on the types of inhibitors that have generated commercial interest, especially amongst drug companies. Insights into the common structural motifs required for active site binding is also discussed.