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Bioprosthetic Aortic Valve Degeneration: a Review from a Basic Science Perspective

2022; Brazilian Society of Cardiovascular Surgery; Volume: 37; Issue: 2 Linguagem: Inglês

10.21470/1678-9741-2020-0635

1678-9741

Tiago R. Velho, Rafael Maniés Pereira, Frederico Leon Arrabal Fernandes, Nuno Carvalho Guerra, Ricardo Ferreira, Ângelo Nobre,

Aortic Disease and Treatment Approaches

Introduction:The increase in the prevalence of aortic stenosis due to an aging population has led to an increasing number of surgical aortic valve replacements.Over the past 20 years, there has been a major shift in preference from mechanical to bioprosthetic valves.However, despite efforts, there is still no "ideal" bioprosthesis.It is crucial to understand the structure, biology, and function of native heart valves to design more intelligent, strong, durable, and physiological heart valve tissues.Methods: A comprehensive review of the literature was performed to identify articles reporting the basic mechanisms of bioprosthetic valve dysfunction and the biology of native valve cells.Searches were run in