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Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India

2021; American Association for the Advancement of Science; Volume: 374; Issue: 6570 Linguagem: Inglês

10.1126/science.abj9932

1095-9203

Mahesh Shanker Dhar, Robin Marwal, Radhakrishnan VS, Kalaiarasan Ponnusamy, Bani Jolly, Rahul C. Bhoyar, Viren Sardana, Salwa Naushin, Mercy Rophina, Thomas A. Mellan, Swapnil Mishra, Charles Whittaker, Saman Fatihi, Meena Datta, Priyanka Singh, Uma Sharma, Rajat Ujjainiya, Nitin Bhatheja, Mohit Kumar Divakar, Manoj Singh, Mohamed Imran, Vigneshwar Senthivel, Ranjeet Maurya, Neha Jha, Priyanka Mehta, A Vivekanand, Pooja Sharma, V. R. Arvinden, Urmila Chaudhary, Namita Soni, Lipi Thukral, Seth Flaxman, Samir Bhatt, Rajesh Pandey, Debasis Dash, Mohammed Faruq, Hemlata Lall, Hema Gogia, Preeti Madan, Sanket Kulkarni, Himanshu Chauhan, Shantanu Sengupta, Sandhya Kabra, Ravindra K. Gupta, Sujeet Kumar Singh, Anurag Agrawal, Partha Rakshit, Vinay Kumar Nandicoori, Karthik Bharadwaj Tallapaka, Divya Tej Sowpati, Kumarasamy Thangaraj, Murali Dharan Bashyam, Ashwin Dalal, Sridhar Sivasubbu, Vinod Scaria, Ajay Parida, Sunil Kumar Raghav, Punit Prasad, Apurva Sarin, Satyajit Mayor, Uma Ramakrishnan, Dasaradhi Palakodeti, Aswin Sai Narain Seshasayee, Manoj Kumar Bhat, Yogesh S. Shouche, Ajay D. Pillai, Tanzin Dikid, Saumitra Das, Arindam Maitra, Sreedhar Chinnaswamy, Nidhan K. Biswas, Anita Desai, Chitra Pattabiraman, M. V. Manjunatha, Reeta S. Mani, Gautam Arunachal Udupi, Priya Abraham, Potdar Varsha Atul, Sarah Cherian,

COVID-19 Clinical Research Studies

Delhi, the national capital of India, experienced multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks in 2020 and reached population seropositivity of >50% by 2021. During April 2021, the city became overwhelmed by COVID-19 cases and fatalities, as a new variant, B.1.617.2 (Delta), replaced B.1.1.7 (Alpha). A Bayesian model explains the growth advantage of Delta through a combination of increased transmissibility and reduced sensitivity to immune responses generated against earlier variants (median estimates: 1.5-fold greater transmissibility and 20% reduction in sensitivity). Seropositivity of an employee and family cohort increased from 42% to 87.5% between March and July 2021, with 27% reinfections, as judged by increased antibody concentration after a previous decline. The likely high transmissibility and partial evasion of immunity by the Delta variant contributed to an overwhelming surge in Delhi.