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Introduction of SARS‐CoV‐2 C.37 (WHO VOI lambda) in the Sao Paulo State, Southeast Brazil

2021; Wiley; Volume: 94; Issue: 3 Linguagem: Inglês

10.1002/jmv.27389

1096-9071

Simone Kashima, Svetoslav Nanev Slavov, Marta Giovanetti, Evandra Strazza Rodrigues, José Salvatore Leister Patané, Vincent Louis Viala, Elaine Vieira Santos, Mariane Evaristo, Loyze Paola Oliveira de Lima, Antonio Jorge Martins, Cláudia Renata dos Santos Barros, Elaine Cristina Marqueze, Pedro Manuel Marques Garibaldi, Natasha Nicos Ferreira, Glenda R. Moraes, Ricardo Augusto Brassaloti, Raquel L. R. C. Cassano, Pilar Mariani, João Paulo Kitajima, David Schlesinger, Rafael dos Santos Bezerra, Patrícia Akemi Assato, Felipe Allan da Silva da Costa, Mirele Poleti, Jéssika Cristina Chagas Lesbon, E. C. Mattos, Cecília Ártico Banho, Lívia Sacchetto, Rejane Maria Tommasini Grotto, Jayme A. Souza‐Neto, Vagner Fonseca, Luíz Carlos Júnior Alcântara, Maurício Lacerda Nogueira, Heidge Fukumasu, Luiz Lehmann Coutinho, Marcos de Carvalho Borges, Rodrigo T. Calado, Maria Carolina Elias, Sandra Coccuzzo Sampaio, Dimas Tadeu Covas,

Viral Infections and Outbreaks Research

The Lambda variants of interest (VOI) (C37/GR/452Q.V1/21G) was initially reported in Lima, Peru but has gained rapid dissemination through other Latin American countries. Nevertheless, the dissemination and molecular epidemiology of the Lambda VOI in Brazil is unknown apart from a single case report. In this respect, we characterized the circulation of the SARS-CoV-2 Lambda VOI (C37/GR/452Q.V1/21G) in Sao Paulo State, Brazil. From March to June 2021, we identified seven Lambda isolates in a set of approximately 8000 newly sequenced genomes of the Network for Pandemic Alert of Emerging SARS-CoV-2 variants from Sao Paulo State. Interestingly, in three of the positive patients, the Lambda VOI infection was probably related to a contact transmission. These individuals were fully vaccinated to COVID-19 and presented mild symptoms. The remaining positive for Lambda VOI individuals showed different levels of COVID-19 symptoms and one of them needed hospitalization (score 5, WHO). In our study, we present a low level of Lambda VOI circulation in the Sao Paulo State. This reinforces the essential role of molecular surveillance for the effective SARS-CoV-2 pandemic response, especially in regard to circulating variants.