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Cannabis Use Is Inversely Associated with Overweight and Obesity in Hepatitis B Virus-Infected Patients (ANRS CO22 Hepather Cohort)

2021; Mary Ann Liebert, Inc.; Volume: 7; Issue: 5 Linguagem: Inglês

10.1089/can.2021.0094

2578-5125

Tangui Barré, Stanislas Pol, Clémence Ramier, Vincent Di Beo, Fabrice Carrat, Morgane Bureau, Marc Bourlière, Céline Dorival, Lawrence Serfaty, Tarik Asselah, Jérôme Boursier, Fabienne Marcellin, Patrizia Carrieri, Hélène Fontaine, Camélia Protopopescu, Laurent Alric, Delphine Bonnet, Virginie Payssan-Sicart, Chloe Pomes, Fabien Zoulim, Marianne Maynard, Roxane Bai, Lucie Hucault, François Bailly, François Raffi, Eric Billaud, D. Boutoille, Maeva Lefebvre, Elisabeth André‐Garnier, Paul Calès, I. Hubert, Adrien Lannes, F. Lunel, Nathalie Boyer, Nathalie Giuily, Corinne Castelnau, Giovanna Scoazec, Emilie Rousseaud, Anaı̈s Vallet-Pichard, Philippe Sogni, Victor de Lédinghen, Juliette Foucher, Jean‐Baptiste Hiriart, Jancell M’Bouyou, Marie Irlès-Depé, Si Nafa Si Ahmed, Valérie Oulès, Albert Tran, Rodolphe Anty, Ève Gelsi, Régine Truchi, Dominique Thabut, Saloua Hammeche, Joseph Moussali, Xavier Causse, Barbara De Dieuleveult, Brahim Ouarani, Damien Labarrière, Nathalie Ganne‐Carrié, Véronique Grando–Lemaire, Pierre Nahon, Séverine Brulé, Betul Ulker, Dominique Guyader, Caroline Jézéquel, Audrey Brener, Anne Laligant, Aline Rabot, Isabelle Renard, François Habersetzer, Thomas F. Baumert, Michel Doffoël, Catherine Schmidt‐Mutter, Pauline Simo‐Noumbissie, Esma Razi, Jean-Pierre Bronowicki, Hélène Barraud, Mouni Bensenane, Abdelbasset Nani, Sarah Hassani-Nani, Marie-Albertine Bernard, Georges‐Philippe Pageaux, Dominique Larrey, M Mészáros, Sophie Métivier, Christophe Bureau, Thibault Morales, Jean Marie Péron, Marie Angèle Robic, Thomas Decaens, Marine Faure, Bruno Froissart, Marie‐Noëlle Hilleret, Jean–Pierre Zarski, Ghassan Riachi, Odile Goria, Fatima Paris, Hélène Montialoux, Vincent Leroy, Giuliana Amaddeo, Anne Varaut, Mélanie Simoes, Rachida Amzal, Olivier Chazouillières, Tony Andréani, Bénédicte Angoulevant, Azeline Chevance, Didier Samuel, Térésa Antonini, Audrey Coilly, Jean‐Charles Duclos Vallée, Mariagrazia Tateo, Armand Abergel, Maud Reymond, Chanteranne Brigitte, Buchard Benjamin, Léon Muti, Claire Geist, Guillaume Conroy, Raphaëlle Riffault, Isabelle Rosa, Camille Barrault, Laurent Costes, Hervé Hagège, V. Loustaud‐Ratti, Paul Carrier, Maryline Debette‐Gratien, Philippe Mathurin, Guillaume Lassailly, Elise Lemaître, V. Canva, Sébastien Dharancy, Alexandre Louvet, Anne Minello, Marianne Latournerie, Marc Bardou, Thomas Mouillot, Louis d’Altéroche, Didier Barbereau, Charlotte Nicolas, Laure Elkrief, Anaïs Jaillais, Jérôme Gournay, Caroline Chevalier, Isabelle Archambeaud, Sarah Habès, Isabelle Portal, Moana Gelu‐Siméon, Eric Saillard, Marie-Josée Lafrance, Lucie Catherine,

Diet, Metabolism, and Disease

Background: Chronic hepatitis B virus (HBV) infection may evolve into cirrhosis and hepatocellular carcinoma, and this progression may be accelerated by specific risk factors, including overweight and obesity. Although evidence for a protective effect of cannabis use on elevated body weight has been found for other populations, no data are available for HBV-infected patients. Aims: We aimed to identify risk factors (including cannabis use) for overweight and obesity in patients with HBV chronic infection. Methods: Using baseline data from the French ANRS CO22 Hepather cohort, we performed two separate analyses, one using "central obesity" (based on waist circumference) and the other "overweight" and "obesity" (based on body mass index) as outcomes. Logistic and multinomial regressions were used to model central obesity and overweight/obesity, respectively. Results: Among the 3706 patients in the study population, 50.8% had central obesity, 34.7% overweight, and 14.4% obesity. After multivariable adjustment, current cannabis use was associated with a 59% lower risk of central obesity compared with no lifetime use (adjusted odds ratio [95% CI]: 0.41 [0.24 to 0.70]). It was also associated with a 54% and 84% lower risk of overweight (adjusted relative risk ratio [95% CI]: 0.46 [0.27 to 0.76]) and obesity (0.16 [0.04 to 0.67]), respectively. Conclusions: Cannabis use was associated with lower risks of overweight and obesity in patients with HBV chronic infection. Future studies should test whether these potential benefits of cannabis and cannabinoid use translate into reduced liver disease progression in this high-risk population.