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Advancing the global public health agenda for NAFLD: a consensus statement

2021; Nature Portfolio; Volume: 19; Issue: 1 Linguagem: Inglês

10.1038/s41575-021-00523-4

1759-5053

Jeffrey V. Lazarus, Henry E. Mark, Quentin M. Anstee, Juan Pablo Arab, Rachel L. Batterham, Laurent Castéra, Helena Cortez‐Pinto, Javier Crespo, Kenneth Cusi, M. Ashworth Dirac, Sven Francque, Jacob George, Hannes Hagström, Terry T.‐K. Huang, Mona Ismail, Achim Kautz, Shiv Kumar Sarin, Rohit Loomba, Veronica Miller, Philip N. Newsome, Michael Ninburg, Ponsiano Ocama, Vlad Ratziu, Mary E. Rinella, Diana Romero, Manuel Romero‐Gómez, Jörn M. Schattenberg, Emmanuel Tsochatzis, Luca Valenti, Vincent Wai‐Sun Wong, Yusuf Yılmaz, Zobair M. Younossi, Shira Zelber‐Sagi, Fredrik Åberg, Leon A. Adams, Maryam Salem Al Khatry, Khalid Al Naamani, Omar Alfaro Murillo, Alina M. Allen, Faisal Abdullatif Alnaser, Saleh A. Alqahtani, Khalid Alswat, Domenico Alvaro, Raúl J. Andrade, Marco Arrese, Yaw Asante Awuku, Motala Ayesha, Oidov Baatarkhuu, Shokhista Bakieva, Rita Basu, Ramón Bataller, Shahinaz Bedri, Emanuele Bosi, Marc Bourlière, Radan Brůha, Elisabetta Bugianesi, Patrizia Burra, Marı́a Buti, Christopher D. Byrne, José Luís Calleja, Patrizia Carrieri, Flloyd Carter, Marlén Ivón Castellanos Fernández, Gabriela Castillo-Lopez, Graciela Castro‐Narro, Henry Lik‐Yuen Chan, Wah‐Kheong Chan, Yoosoo Chang, Massimo Colombo, Kirsten Coppell, Kathleen E. Corey, Antonio Craxı̀, Donna R. Cryer, Anuradha Supun Dassanayake, Antonieta de Ascenção Soares Martins, Victor de Lédinghen, Stefano DelPrato, Alessandro Demaio, Hailemichael Desalegn, John Dillon, Ajay Duseja, Dorairaj Prabhakaran, Mattias Ekstedt, Mohamed El‐Kassas, Osama Mohamed Elsanousi, Gamal Esmat, Jian‐Gao Fan, Nathalie J. Farpour‐Lambert, Robert Flisiak, Yasser Fouad, Michael Fuchs, Rino Alvani Gani, Lynn H. Gerber, Hasmik Ghazinyan, Liana Gheorghe, George Boon‐Bee Goh, Henning Grønbæk, Aghayeva Gulnara, Saeed Hamid, Vanessa Hebditch, Ingrid J. Hickman, Samantha Hocking, Béla Hunyady, Ramazan İdilman, Isakov Va, Mohammad H. Jamal, Peter Jepsen, Natacha Jreige Iskandar, Myeong Jun Song, K. C. Sudhamshu, Satoru Kakizaki, George Kalamitsis, Fasiha Kanwal, Jia‐Horng Kao, Lee M. Kaplan, Takumi Kawaguchi, Yousef Khader, Seung Up Kim, Nicolas Kodjoh, Ger H. Koek, Kazuhiko Koike, Narcisse Komas, Marko Korenjak, Marcelo Kugelmas, A. Labidi, Naomi F. Lange, Joel E. Lavine, Mariana Lazo, Nancy Y. Lee, Cosmas Rinaldi Adithya Lesmana, Chun‐Jen Liu, Michelle T. Long, Patricio López‐Jaramillo, Reza Malekzadeh, Mamun Al Mahtab, Giulio Marchesini, Rui Tato Marinho, S Vázquez, Lyudmila Mateva, Charles Mbendi Nlombi, P. Mélin, Ivana Mikolašević, Tamara Alempijević, Carla Musso, Atsushi Nakajima, Edna Nava, Alexander Nersesov, Dafina Nikolova, Suzanne Norris, Katja Novak, Jude A. Oben, Janus P. Ong, Charles Onyekwere, George Papatheodoridis, Imran Paruk, Keyur Patel, Maria Paula Macedo, Carlos Penha‐Gonçalves, Marlene Pérez Figueroa, Wolf Peter Hofmann, Salvatore Petta, Cláudia P. Oliveira, Puneet Puri, Calvin Q. Pan, Marek Rác, Johanna Ralston, Alnoor Ramji, Homie Razavi, Mário Reis Álvares‐da‐Silva, Stuart K. Roberts, Michael Roden, Tamsin Rose, Samir Rouabhia, Patrizia Rovere‐Querini, Ian Rowe, Shakhlo Sadirova, Riina Salupere, Tobokalova Saparbu, Raymond Sayegh, Giada Sebastiani, Yosuke Seki, Josefina Selmo, Abdel Karim Sermé, Jonathan E. Shaw, K T Shenoy, Nick Sheron, Oren Shibolet, Marcelo Silva, I. Skrypnyk, Piotr Socha, Joan B. Soriano, C Wendy Spearman, Kannan Sridharan, Juan José Suárez, Dhastagir Sultan Sheriff, Ki‐Chul Sung, Mark G. Swain, Frank Tacke, Shahrad Taheri, Soek-Siam Tan, Elliot B. Tapper, Hannele Yki‐Järvinen, Maja Thiele, Isaac Thom Shawa, Ieva Tolmane, Esther A. Torres, Michael Trauner, Sombat Treeprasertsuk, Adela Turcanu, Jonas Valantinas, Mette Vesterhus, Imam Waked, Sarah H. Wild, José Willemse, Robert J. Wong, Stavra A. Xanthakos, Dan Yock Young, Ming‐Lung Yu, Kenneth I. Zheng, Mudjat Zeybel, Ming‐Hua Zheng,

Hepatocellular Carcinoma Treatment and Prognosis

Non-alcoholic fatty liver disease (NAFLD) is a potentially serious liver disease that affects approximately one-quarter of the global adult population, causing a substantial burden of ill health with wide-ranging social and economic implications. It is a multisystem disease and is considered the hepatic component of metabolic syndrome. Unlike other highly prevalent conditions, NAFLD has received little attention from the global public health community. Health system and public health responses to NAFLD have been weak and fragmented, and, despite its pervasiveness, NAFLD is largely unknown outside hepatology and gastroenterology. There is only a nascent global public health movement addressing NAFLD, and the disease is absent from nearly all national and international strategies and policies for non-communicable diseases, including obesity. In this global Delphi study, a multidisciplinary group of experts developed consensus statements and recommendations, which a larger group of collaborators reviewed over three rounds until consensus was achieved. The resulting consensus statements and recommendations address a broad range of topics — from epidemiology, awareness, care and treatment to public health policies and leadership — that have general relevance for policy-makers, health-care practitioners, civil society groups, research institutions and affected populations. These recommendations should provide a strong foundation for a comprehensive public health response to NAFLD. Non-alcoholic fatty liver disease (NAFLD) is a potentially serious liver disease with a substantial burden worldwide. In this Consensus Statement, a global multidisciplinary group of experts develop consensus statements and recommendations addressing a broad range of topics on NAFLD to raise awareness and spur action.