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Diagnostic approach to neonatal and infantile cholestasis: A position paper by the SIGENP liver disease working group

2021; Elsevier BV; Volume: 54; Issue: 1 Linguagem: Inglês

10.1016/j.dld.2021.09.011

1878-3562

Giusy Ranucci, Claudia Della Corte, Daniele Alberti, Maria Pia Bondioni, Giovanni Boroni, Pier Luigi Calvo, Mara Cananzi, M. Candusso, Maria Grazia Clemente, Lorenzo D’Antiga, Irene Degrassi, Jean de Ville de Goyet, Fabiola Di Dato, Angelo Di Giorgio, Carlo Dionisi‐Vici, Federica Ferrari, Paola Francalanci, Maurizio Fuoti, Fabio Fusaro, Paola Gaio, Chiara Grimaldi, Maria Iascone, Giuseppe Indolfi, Raffaele Iorio, Giuseppe Maggiore, Claudia Mandato, Lorenza Matarazzo, Lidia Monti, Fabio Mosca, Gabriella Nebbia, Federica Nuti, Giulia Paolella, Michele Pinon, Paola Roggero, Marco Sciveres, Daniele Serranti, Marco Spada, Pietro Vajro, Emanuele Nicastro,

Gallbladder and Bile Duct Disorders

Neonatal and infantile cholestasis (NIC) can represent the onset of a surgically correctable disease and of a genetic or metabolic disorder worthy of medical treatment. Timely recognition of NIC and identification of the underlying etiology are paramount to improve outcomes.Upon invitation by the Italian National Institute of Health (ISS), an expert working grouped was formed to formulate evidence-based positions on current knowledge about the diagnosis of NIC.A systematic literature search was conducted to collect evidence about epidemiology, etiology, clinical aspects and accuracy of available diagnostic tests in NIC. Evidence was scored using the GRADE system. All recommendations were approved by a panel of experts upon agreement of at least 75% of the members. The final document was approved by all the panel components.This position document summarizes the collected statements and defines the best-evidence diagnostic approach to cholestasis in the first year of life.