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Higher mortality associated with the SARS-CoV-2 Delta variant in the Western Cape, South Africa, using RdRp target delay as a proxy

2021; Cold Spring Harbor Laboratory; Linguagem: Inglês

10.1101/2021.10.23.21265412

Hannah Hussey, Mary‐Ann Davies, Alexa Heekes, Carolyn Williamson, Ziyaad Valley‐Omar, Diana Hardie, Stephen N.J. Korsman, Deelan Doolabh, Wolfgang Preiser, Tongai Maponga, Arash Iranzadeh, Susan Engelbrecht, Sean Wasserman, Neshaad Schrueder, Linda Boloko, Greg Symons, Peter Raubenheimer, Abraham Viljoen, Arifa Parker, Cheryl Cohen, Waasila Jassat, Richard Lessells, Robert J. Wilkinson, Andrew Boulle, Marvin Hsiao,

COVID-19 Clinical Research Studies

Abstract A novel proxy for the Delta variant, RNA-dependent RNA polymerase target delay in the Seegene Allplex™ 2019-nCoV PCR assay, was associated with higher mortality (adjusted Odds Ratio 1.45 [95%CI 1.13-1.86]), compared to presumptive Beta infection, in the Western Cape, South Africa (April-July 2021). Prior diagnosed infection and vaccination were protective.