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Acute Lymphoblastic Leukemia in Children: Better Transplant Outcomes After Total Body Irradiation-based Conditioning

2021; Stanford University Highwire Press; Volume: 35; Issue: 6 Linguagem: Inglês

10.21873/invivo.12627

1791-7549

Jan Styczyński, Robert Dębski, K Czyźewski, Katarzyna Gągola, EWA MARQUARDT, Krzysztof Roszkowski, Janusz Winiecki, Ninela Irga‐Jaworska, Marcin Hennig, Katarzyna Muszyńska‐Rosłan, Marcin Płonowski, Tomasz Ociepa, Monika Łęcka, Joanna Konieczek, Przemysław Gałązka, Monika Pogorzała, Monika Richert-Przygońska, Mariusz Wysocki,

Polyomavirus and related diseases

Comparison of transplant outcomes in long-term follow-up of children after total body irradiation (TBI)- or chemotherapy-based conditioning allogeneic hematopoietic cell transplantation (allo-HCT).Patients undergoing allo-HCT for Acute lymphoblastic leukemia (ALL) conditioned either with TBI (n=55) or chemotherapy (n=84) were compared. The following transplant outcomes were analyzed: overall survival (OS), event-free survival (EFS), relapse incidence (RI), and graft-versus-host-disease (GVHD)-free-relapse-free survival (GRFS).All analyzed long-term transplant outcomes were significantly better for patients conditioned with TBI at 2 years after transplant. OS at 2 years was 84% after TBI and 60.5% after chemotherapy-conditioning (p=0.005). Risk factor analysis showed that two factors, TBI-based conditioning and transplant in first remission of ALL, significantly improved OS, EFS, GRFS, and decreased RI.TBI-based conditioning before allogeneic HCT in children with acute lymphoblastic leukemia provides significantly better transplant outcomes, when compared to chemotherapy-based conditioning.