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T-cell and antibody responses to first BNT162b2 vaccine dose in previously infected and SARS-CoV-2-naive UK health-care workers: a multicentre prospective cohort study

2021; Elsevier BV; Volume: 3; Issue: 1 Linguagem: Inglês

10.1016/s2666-5247(21)00275-5

2666-5247

Adrienn Angyal, Stéphanie Longet, Shona C. Moore, Rebecca P. Payne, Adam Harding, Tom Tipton, Patpong Rongkard, Mohammad Ali, Luisa M. Hering, Naomi Meardon, James E. Austin, Rebecca Brown, Donal Skelly, Natalie Gillson, Sue L. Dobson, Andrew Cross, Gurjinder Sandhar, Jonathan A. Kilby, Jessica K. Tyerman, Alexander R. Nicols, Jarmila Stremenova Spegarova, Hema Mehta, Hailey Hornsby, Rachel Whitham, Christopher P. Conlon, Katie Jeffery, Philip Goulder, John Frater, Christina Dold, Matthew Pace, Ane Ogbe, Helen Brown, M. Azim Ansari, Emily Adland, Anthony Brown, Meera Chand, Adrian M. Shields, Philippa C. Matthews, Susan Hopkins, Victoria Hall, William James, Sarah Rowland–Jones, Paul Klenerman, Susanna Dunachie, Alex Richter, C.J. Duncan, Eleanor Barnes, Miles W. Carroll, Lance Turtle, Thushan I. de Silva, Adam Harding, Adam Watson, Adrian M. Shields, Adrienn Angyal, Ahmed Alhussni, Alex Richter, Alexander R. Nicols, Alexandra Deeks, Alice Webb-Bridges, Andrew Cross, Ane Ogbe, Anni Jämsén, Anthony Brown, Anu Chawla, Christina Dold, C.J. Duncan, Christopher P. Conlon, Donal Skelly, Denise O’Donnell, Eleanor Barnes, Emily Adland, Esme Weeks, Gurjinder Sandhar, Hailey Hornsby, Helen Brown, Hema Mehta, Hibatullah Abuelgasim, Huiyuan Xiao, James E. Austin, Jarmila Stremenova Spegarova, Jennifer Holmes, Jenny Haworth, Jessica K. Tyerman, John Frater, Jonathan A. Kilby, Joseph Cutteridge, Katie Jeffery, Katy Lillie, Lance Turtle, Leigh Romaniuk, Lucy Denly, Luisa M. Hering, M. Azim Ansari, Matthew Pace, Meera Chand, Miles W. Carroll, Mohammad Ali, Mwila Kasanyinga, Naomi Meardon, Natalie Gillson, Patpong Rongkard, Paul Klenerman, Philip Goulder, Philippa C. Matthews, Rachel Whitham, Rebecca Brown, Rebecca P. Payne, Robert Wilson, Sarah Rowland–Jones, Sarah Thomas, Shona C. Moore, Siobhan Gardiner, Stéphanie Longet, Stephanie Tucker, Sue L. Dobson, Susan Hopkins, Susanna Dunachie, Syed Adlou, Thushan I. de Silva, Tom Tipton, Victoria Hall, William James, Allan Lawrie, Nikki Smith, H. Turton, Amira Zawia, Martin Bayley, Alex Fairman, Kate Harrington, Rosemary Kirk, Louise Marsh, Lisa Watson, Steven C. Wood, Benjamin Diffey, Christopher R. Jones, Lauren Lett, Gareth Platt, Krishanthi Subramaniam, Dan Wootton, Brendan Payne, Sophie Hambleton, Sinéad Kelly, J. H. MARSTON, Sonia Poolan, Dianne Turner, Muzlifah Haniffa, Emily Stephenson, Sandra Adele, Hossain Delowar Akhter, Senthil Chinnakannan, Catherine de Lara, Timothy Donnison, Carl-Philipp Hackstein, Lian Ni Lee, Nicholas Lim, Tom Malone, Eloise Phillips, Narayan Ramamurthy, Nichola Robinson, Oliver Sampson, David W. Eyre, Beatrice Simmons, Lizzie Stafford, Alexander J. Mentzer, Ali Amini, Carolina V. Arancibia-Cárcamo, Nicholas M. Provine, Simon Travis, Stavros Dimitriadis, Síle A. Johnson, Sarah Foulkes, Jameel Khawam, Edgar Wellington, Javier Gilbert‐Jaramillo, Michael L. Knight, Maeva Dupont, Emily C. Horner, James Thaventhiran, Jeremy Chalk,

Infection Control and Ventilation

Previous infection with SARS-CoV-2 affects the immune response to the first dose of the SARS-CoV-2 vaccine. We aimed to compare SARS-CoV-2-specific T-cell and antibody responses in health-care workers with and without previous SARS-CoV-2 infection following a single dose of the BNT162b2 (tozinameran; Pfizer-BioNTech) mRNA vaccine.