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Safety and immediate humoral response of COVID-19 vaccines in chronic kidney disease patients: the SENCOVAC study

2021; Oxford University Press; Volume: 37; Issue: 10 Linguagem: Inglês

10.1093/ndt/gfab313

1460-2385

Borja Quiroga, María José Soler, Alberto Ortíz, Shaira Martínez Vaquera, Carlos Jesús Jarava Mantecón, Gustavo Useche, Marı́a Gabriela Márquez, Manuel Torralba Carnerero, Maria Teresa Jaldo Rodríguez, Patricia Muñoz Ramos, Juan Carlos Ruiz, Néstor Toapanta, Carolina Gracia-Iguacel, María Cinta Aguilar Cervera, Noelia Balibrea Lara, Alba Leyva, José Antonio Muñoz Rojas, Ron T. Gansevoort, Patricia de Sequera, José Luis Pizarro León, Manuel Antonio Martínez García, Benaldina García Jiménez, Virginia Olinda Gómez Pérez, Juan de Dios Ramiro Moya, Diana López Espinosa, Alejandro Jiménez Herrador, Manuel Navarro Zurita, Leonardo Díaz Álvarez, Álvaro González Martínez, Sandra Báez Arroyo, Raquel Reina Fernández, Marlyn Janella Suárez Vargas, Rocío Calurano Casero, Amparo Bernat García, Ana Beatriz Muñoz Díaz, Carmen Santamaría de Miguel, Ángel Palacios, Brenda Henningsmeyer, Esther Orero Calve, José Lacueva Moya, Yurika Sato, Marta Serra Marín, Carolina Lancho Novillo, Pedro Luis Quirós Ganga, Fernando Vallejo Carrión, Antonio Luis García Herrera, Irene Torres, Pablo Delgado Conde, Georgina Alfaro, Olga Halauko, Fouad El Rifai, Ana Dolores Martínez, Rafael Lucena Valverde, Marta Puerta Carretero, Mayra Ortega Díaz, Daniel Gaitán Tocora, Esther Rodriguez Suárez, Alfredo José Sáenz Santolaya, Sandra Castellano Gash, Lara Ruíz Martínez, Yohana Gil Giraldo, Martín Giorgi, Sánchez González, Ana Sánchez Horrillo, Pablo Ruano Suárez, Antonio Fernández Perpén, Andrés Fernández, Laura Salanova Villanueva, Alejandra Cortiñas, Pablo A Díez Arias, Alicia Cabrera Cárdenas, Antonio de Santos, Almudena Hernández Núñez, Guillermina Barril Cuadrado, Raquel Repollet, Rosalía Valero, Celestino Piñera Haces, María Kislikova, Emilio Rodrigo, Francesc Moreso, Emilio González‐Parra, Catalina Martín-Cleary, Jinny Sánchez-Rodríguez y Ana Ramos-Verde, María Teresa Rodrigo De Tomas, Beatriz Azcue Prieto, Carmen Toyos Y José Molina Del Rio, Adriana Restrepo Acosta, Amagoia Celayeta Zamacona, Francisco Contreras, Dioné González Ferri, Eduardo Muñoz de Bustillo Llorente, Núria García-Fernández, Paloma Leticia Martin Moreno, Noelia Ania González, Ana Sabalza Ortiz, María Nieves Bastida Iñarrea, Ana M. Tato Ribera, Eduardo Gallego Valcarce, Enrique Gruss Vergara, María Rosario Llópez Carratalá, Leyre María Martin Rodríguez, Marisa Serrano Salazar, Begoña Prieto, José Pórtoles, M. Martin, Saioa Bilbao Ortega, Ma Isabel Gallardo Ruiz, A Rubio, Paula Garcia Ledesma, Alvaro Goyoaga Alvarez, Natalia Blanco Castro, Augusto Quiroz Morales, Ignacio Manzur Cavalotti, Itziar Navarro Zorita, Sol Otero López, Sara Outon González, Carlos Soto Montañez, Esteban Poch, David Cucchiari, José Jesús Broseta, Auxiliadora Mazuecos, Juan Manuel Cazorla, Teresa Garcı́a, Carlos F. Narváez, Cristhian Orellana, Nicolás Macías Carmona, David Arroyo Rueda, María Luisa Rodríguez Ferrero, Almudena Vega Martínez, Soraya Abad Estébanez, Jesús Calviño Varela, Alba García Enríquez, Carmen Cobelo Casas, Pablo Otero Alonso, Lourdes González Tabarés, Laura Muñiz Pacios, Lina León Machado, Isabel Berdud Godoy, Esther Torres Aguilera, Rolando Tello Alea, Margie Soledad Del Rosario Saldaña, Maria Antònia Munar Vila, Soledad Pizarro Sánchez, Simona Alexandru, Laura García Puente Suarez, Saúl Pampa Saico, Marisol Poma Tapia, Virginia Lopez De La Manzanara Perez, Marta Calvo Arevalo, José Antonio Herrero Calvo, Auxiliadora Bajo Rubio, Gloria del Peso Gilsanz, Marta Ossorio Gonzalez, Rafael Sánchez, María O. López‐Oliva, Antonio Gil Paraiso, Marta Sanz Sainz, Maria Laura Salvetti, María Cufi Valmajor, Montserrat Picazo Sánchez, Miriam Llado Barragán, Laia Reixach Aunatell, Beatriz Escamilla Cabrera, Aurelio Pastor Rodríguez Hernández, María Sagrario García Rebollo, Juana Margarita Rufino Hernández, José María Lamas Barreiro, Sofía Zárraga Larrondo, Joaquín Manrique, Alejandra Yugueros González, Antonio Marín Franco, Lucía Sobrino Díaz, Pilar Sánchez‐Pérez, Adelaida Morales Umpierrez, Esther Hurtado Ruiz, Aránzazu Márquez Corbella, Katia Toledo Perdomo, Yasmina Martín Martín, Blanca Villacorta Linaza, Antonio Galán Serrano, Patricia Tomás Simó, Humberto Daniel Rojas Mancilla, Marta Poves Gómez, J. Gumpert, Secundino Cigarrán, Rosa Sánchez Hernández, Enriqueta González Rodríguez, Gabriel de Arriba, Rosa María Ruiz-Calero Cendrero, José María Baltar Martín, José Ignacio Mínguela Pesquera, Pablo Justo Ávila, Eva Cotilla de la Rosa,

Vaccine Coverage and Hesitancy

Chronic kidney disease (CKD) patients are at high-risk for severe coronavirus disease 2019 (COVID-19). The multicentric, observational and prospective SENCOVAC study aims to describe the humoral response and safety of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in CKD patients. Safety and immediate humoral response results are reported here.Four cohorts of patients were included: kidney transplant (KT) recipients, and haemodialysis (HD), peritoneal dialysis (PD) and non-dialysis CKD patients from 50 Spanish centres. Adverse events after vaccine doses were recorded. At baseline and on Day 28 after the last vaccine dose, anti-Spike antibodies were measured and compared between cohorts. Factors associated with development of anti-Spike antibodies were analysed.A total of 1746 participants were recruited: 1116 HD, 171 PD, 176 non-dialysis CKD patients and 283 KT recipients. Most patients (98%) received mRNA vaccines. At least one vaccine reaction developed after the first dose in 763 (53.5%) and after the second dose in 741 (54.5%) of patients. Anti-Spike antibodies were measured in the first 301 patients. At 28 days, 95% of patients had developed antibodies: 79% of KT, 98% of HD, 99% of PD and 100% of non-dialysis CKD patients (P < 0.001). In a multivariate adjusted analysis, absence of an antibody response was independently associated with KT (odds ratio 20.56, P = 0.001) and with BNT162b2 vaccine (odds ratio 6.03, P = 0.023).The rate of anti-Spike antibody development after vaccination in KT patients was low but in other CKD patients it approached 100%, suggesting that KT patients require persistent isolation measures and booster doses of a COVID-19 vaccine. Potential differences between COVID-19 vaccines should be explored in prospective controlled studies.