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Association Between Antemortem FLAIR White Matter Hyperintensities and Neuropathology in Brain Donors Exposed to Repetitive Head Impacts

2021; Lippincott Williams & Wilkins; Volume: 98; Issue: 1 Linguagem: Inglês

10.1212/wnl.0000000000013012

1526-632X

Madeline Uretsky, Sylvain Bouix, Ronald Killiany, Yorghos Tripodis, Brett Martin, Joseph Palmisano, Asim Mian, Karen Buch, Chad W. Farris, Daniel H. Daneshvar, Brigid Dwyer, Lee E. Goldstein, Douglas I. Katz, Christopher J. Nowinski, Robert C. Cantu, Neil W. Kowall, Bertrand R. Huber, Robert A. Stern, Victor E. Alvarez, Thor D. Stein, Ann C. McKee, Jesse Mez, Michael L. Alosco,

Cerebrospinal fluid and hydrocephalus

Late neuropathologies of repetitive head impacts from contact sports can include chronic traumatic encephalopathy (CTE) and white matter degeneration. White matter hyperintensities (WMH) on fluid-attenuated inversion recovery (FLAIR) MRI scans are often viewed as microvascular disease from vascular risk, but might have unique underlying pathologies and risk factors in the setting of repetitive head impacts. We investigated the neuropathologic correlates of antemortem WMH in brain donors exposed to repetitive head impacts. The association between WMH and repetitive head impact exposure and informant-reported cognitive and daily function were tested.