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Revisão Acesso aberto Produção Nacional
BIBTEX RIS

Recommendations of the Brazilian Society of Rheumatology for the use of JAK inhibitors in the management of rheumatoid arthritis

2021; BioMed Central; Volume: 61; Issue: 1 Linguagem: Inglês

10.1186/s42358-021-00228-x

ISSN

2523-3106

Autores

Karina Rossi Bonfiglioli, Lícia Maria Henrique da Mota, Ana Cristina de Medeiros Ribeiro, Adriana María Kakehasi, Iêda Maria Magalhães Laurindo, Rina Dalva Neubarth Giorgi, Ângela Luzia Branco Pinto Duarte, Ana Paula Monteiro Gomides, Mariana Peixoto Guimarães Ubirajara e Silva de Souza, Claiton Viegas Brenol, Geraldo da Rocha Castelar Pinheiro, Cleandro Pires de Albuquerque, Charlles Heldan de Moura Castro, Gustavo Luiz Behrens Pinto, José Fernando Verztman, Luciana Feitosa Muniz, Manoel Barros Bértolo, Maria Raquel da Costa Pinto, Paulo Louzada‐Júnior, Vítor Alves Cruz, Ivânio Alves Pereira, Max Vitor Carioca Freitas, Bóris Afonso Cruz, Eduardo dos Santos Paiva, Odirlei André Monticielo, José Roberto Provenza, Ricardo Machado Xavier,

Tópico(s)

Cytokine Signaling Pathways and Interactions

Resumo

Abstract Rheumatoid arthritis (RA) is a chronic and autoimmune systemic inflammatory disease that can cause irreversible joint deformities, with increased morbidity and mortality and a significant impact on the quality of life of the affected individual. The main objective of RA treatment is to achieve sustained clinical remission or low disease activity. However, up to 40% of patients do not respond to available treatments, including bDMARDs. New therapeutic targets for RA are emerging, such as Janus kinases (JAKs). These are essential for intracellular signaling (via JAK-STAT) in response to many cytokines involved in RA immunopathogenesis. JAK inhibitors (JAKi) have established themselves as a highly effective treatment, gaining increasing space in the therapeutic arsenal for the treatment of RA. The current recommendations aim to present a review of the main aspects related to the efficacy and safety of JAKis in RA patients, and to update the recommendations and treatment algorithm proposed by the Brazilian Society of Rheumatology in 2017.

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