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Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels.

1996; Springer Nature; Volume: 15; Issue: 13 Linguagem: Inglês

10.1002/j.1460-2075.1996.tb00697.x

1460-2075

Jean‐Philippe Hugnot, Miguel Salinas, Florian Lesage, Eric Guillemare, Jan de Weille, Catherine Heurteaux, Marie‐Geneviève Mattéi, Michel Lazdunski,

Cardiac electrophysiology and arrhythmias

Research Article1 July 1996free access Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels. J. P. Hugnot J. P. Hugnot Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, Valbonne, France. Search for more papers by this author M. Salinas M. Salinas Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, Valbonne, France. Search for more papers by this author F. Lesage F. Lesage Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, Valbonne, France. Search for more papers by this author E. Guillemare E. Guillemare Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, Valbonne, France. Search for more papers by this author J. de Weille J. de Weille Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, Valbonne, France. Search for more papers by this author C. Heurteaux C. Heurteaux Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, Valbonne, France. Search for more papers by this author M. G. Mattéi M. G. Mattéi Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, Valbonne, France. Search for more papers by this author M. Lazdunski M. Lazdunski Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, Valbonne, France. Search for more papers by this author J. P. Hugnot J. P. Hugnot Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, Valbonne, France. Search for more papers by this author M. Salinas M. Salinas Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, Valbonne, France. Search for more papers by this author F. Lesage F. Lesage Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, Valbonne, France. Search for more papers by this author E. Guillemare E. Guillemare Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, Valbonne, France. Search for more papers by this author J. de Weille J. de Weille Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, Valbonne, France. Search for more papers by this author C. Heurteaux C. Heurteaux Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, Valbonne, France. Search for more papers by this author M. G. Mattéi M. G. Mattéi Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, Valbonne, France. Search for more papers by this author M. Lazdunski M. Lazdunski Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, Valbonne, France. Search for more papers by this author Author Information J. P. Hugnot1, M. Salinas1, F. Lesage1, E. Guillemare1, J. Weille1, C. Heurteaux1, M. G. Mattéi1 and M. Lazdunski1 1Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, Valbonne, France. The EMBO Journal (1996)15:3322-3331https://doi.org/10.1002/j.1460-2075.1996.tb00697.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Outward rectifier K+ channels have a characteristic structure with six transmembrane segments and one pore region. A new member of this family of transmembrane proteins has been cloned and called Kv8.1. Kv8.1 is essentially present in the brain where it is located mainly in layers II, IV and VI of the cerebral cortex, in hippocampus, in CA1-CA4 pyramidal cell layer as well in granule cells of the dentate gyrus, in the granule cell layer and in the Purkinje cell layer of the cerebellum. The Kv8.1 gene is in the 8q22.3–8q24.1 region of the human genome. Although Kv8.1 has the hallmarks of functional subunits of outward rectifier K+ channels, injection of its cRNA in Xenopus oocytes does not produce K+ currents. However Kv8.1 abolishes the functional expression of members of the Kv2 and Kv3 subfamilies, suggesting that the functional role of Kv8.1 might be to inhibit the function of a particular class of outward rectifier K+ channel types. Immunoprecipitation studies have demonstrated that inhibition occurs by formation of heteropolymeric channels, and results obtained with Kv8.1 chimeras have indicated that association of Kv8.1 with other types of subunits is via its N-terminal domain. Previous ArticleNext Article Volume 15Issue 131 July 1996In this issue RelatedDetailsLoading ...