Sequential immunization of macaques elicits heterologous neutralizing antibodies targeting the V3-glycan patch of HIV-1 Env
2021; American Association for the Advancement of Science; Volume: 13; Issue: 621 Linguagem: Inglês
10.1126/scitranslmed.abk1533
ISSN1946-6242
AutoresAmelia Escolano, Harry B. Gristick, Rajeev Gautam, Andrew T. DeLaitsch, Morgan E. Abernathy, Zhi Yang, Haoqing Wang, Magnus A. G. Hoffmann, Yoshiaki Nishimura, Zijun Wang, Nicholas Koranda, Leesa M. Kakutani, Han Gao, Priyanthi N.P. Gnanapragasam, Henna Raina, Ana Gazumyan, Melissa Cipolla, Thiago Y. Oliveira, Víctor Ramos, Darrell J. Irvine, Murillo Silva, Anthony P. West, Jennifer R. Keeffe, Christopher O. Barnes, Michael S. Seaman, Michel C. Nussenzweig, Malcolm A. Martin, Pamela J. Björkman,
Tópico(s)T-cell and B-cell Immunology
ResumoSequential immunization elicits antibodies against the V3-glycan patch of HIV-1 Env in rhesus macaques and also induces off-target antibody responses.
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