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BIBTEX RIS

Trend analysis of carbapenem-resistant Gram-negative bacteria and antimicrobial consumption in the post-COVID-19 era: an extra challenge for healthcare institutions

2021; Elsevier BV; Volume: 120; Linguagem: Inglês

10.1016/j.jhin.2021.11.011

1532-2939

Viviane Maria de Carvalho Hessel Dias, Felipe Francisco Tuon, Patrícia de Jesus Capelo, João Paulo Telles, Carlos Magno Castelo Branco Fortaleza, Cristina Pellegrino Baena,

Global Maternal and Child Health

The incidence density trend of the carbapenem-resistant Gram-negative bacteria was analysed in device-associated infections and antimicrobial consumption in 99 critical care facilities in a low/middle-income country, between January 2019 and December 2020. Carbapenem-resistant Acinetobacter baumannii (CRAB) per 1000 patient-days increased in 2020 and this finding had a strong positive correlation with the incidence density of COVID-19 by the Spearman test. Polymyxin consumption also increased in 2020 but without significant correlation with CRAB or COVID-19 incidence density, presumably due to empirical and untargeted prescribing as a consequence of concern about CRAB infections. These findings are a warning to infection control programmes and antimicrobial stewardship.