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Association between Hypertriglyceridemia and Disease Severity in Visceral Leishmaniasis

2021; American Society of Tropical Medicine and Hygiene; Volume: 106; Issue: 2 Linguagem: Inglês

10.4269/ajtmh.21-0260

1476-1645

Mariana Garcez Varela, Mariana de Oliveira Bezerra, Felipe Vieira Santana, Marcos Couto Gomes, Pedro Ribeiro de Jesus Almeida, Geydson Silveira da Cruz, Enaldo Vieira de Melo, Paulo Roberto de Oliveira Costa, Fabrícia Alvisi de Oliveira, Amélia Ribeiro de Jesus, Roque Pacheco de Almeida,

Paraoxonase enzyme and polymorphisms

ABSTRACT. Visceral leishmaniasis (VL) is a tropical disease endemic to Brazil. The clinical manifestations of the infection range from asymptomatic to severe. In VL, changes in lipid metabolism, such as hypocholesterolemia and hypertriglyceridemia, occur that are believed to be related to its progression and severity. This study investigated the associations between serum levels of cholesterol, triglycerides, and lipoproteins (high-density lipoprotein, low-density lipoprotein, and very low-density lipoprotein) with clinical and hematological parameters that predict severity in a case series of 83 VL patients. Severely ill patients had higher mean serum triglyceride levels than non-severely ill patients. There was a significant positive correlation between disease severity score and serum triglyceride levels, very low-density lipoprotein, international normalized ratio for prothrombin time test, total bilirubin, and age. An inverse correlation was detected between the disease severity score and mean platelet and neutrophil counts. Hypertriglyceridemia can be a prognostic indicator of severity in patients diagnosed with VL.