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The primary structure of the murine multifinger gene mKr2 and its specific expression in developing and adult neurons.

1988; Springer Nature; Volume: 7; Issue: 5 Linguagem: Inglês

10.1002/j.1460-2075.1988.tb02950.x

1460-2075

Kamal Chowdhury, Gregory R. Dressler, Georg Breier, Urban Deutsch, Peter Gruß,

Cancer Mechanisms and Therapy

Research Article1 May 1988free access The primary structure of the murine multifinger gene mKr2 and its specific expression in developing and adult neurons. K. Chowdhury K. Chowdhury Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Göttingen. Search for more papers by this author G. Dressler G. Dressler Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Göttingen. Search for more papers by this author G. Breier G. Breier Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Göttingen. Search for more papers by this author U. Deutsch U. Deutsch Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Göttingen. Search for more papers by this author P. Gruss P. Gruss Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Göttingen. Search for more papers by this author K. Chowdhury K. Chowdhury Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Göttingen. Search for more papers by this author G. Dressler G. Dressler Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Göttingen. Search for more papers by this author G. Breier G. Breier Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Göttingen. Search for more papers by this author U. Deutsch U. Deutsch Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Göttingen. Search for more papers by this author P. Gruss P. Gruss Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Göttingen. Search for more papers by this author Author Information K. Chowdhury1, G. Dressler1, G. Breier1, U. Deutsch1 and P. Gruss1 1Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Göttingen. The EMBO Journal (1988)7:1345-1353https://doi.org/10.1002/j.1460-2075.1988.tb02950.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The complete amino acid sequence of the murine finger-containing gene mKr2 was determined. On the basis of sequence similarities in the repeated finger domain, mKr2 belongs to the same class of developmentally expressed genes as Drosophila Krüppel and hunchback. The presence of metal ion and DNA-binding finger domains similar to those identified in TFIIIA supports the hypothesis that these genes regulate transcription. mKr2 transcripts are restricted to neurons in the central and peripheral nervous system of adult animals. Furthermore, mKr2 transcripts can be detected in all the major structures of the developing nervous system during embryogenesis. The data are consistent with the hypothesis that mKr2 is a regulatory factor required for the differentiation and/or phenotypic maintenance of neurons. Previous ArticleNext Article Volume 7Issue 51 May 1988In this issue RelatedDetailsLoading ...