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Erythroid differentiation during stem cell proliferation.

1967; National Institutes of Health; Volume: 70; Issue: 1 Linguagem: Inglês

Richard L. DeGowin,

Ultrasound and Hyperthermia Applications

Mice were protected from radiation-induced bone marrow death by shielding a portion of their bone marrow (femoral marrow) from supralethal doses of x-rays. Hemopoietic colonies developed to macroscopic size in the spleen about 4 days after irradiation. Subsequently, atrophic spleens gained mass and exceeded normal spleens in weight &ring the second weelc postirradiation. Splenic uptake of IslZ-labeled iododeoxyzcridine increased during the first 4 days and reached a peak of about twice normal 8 days after irradiation. In contrast, splenic uptake of radioiron (59Fe) did not increase until the fifth day after irradiation. Erythropoietin faded to increase splenio uptake of 59Fe 0% the fifth day. Peripheral blood cell counts began to increase toward the end of the first week and the beginning of the second week after irradiation. The results were interpreted as evidence that stem cells in a state of cell cycle are not available for eryth.roid differendiation.