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Actinomycin inhibition of in vitro protein synthesis in rat liver

1963; Elsevier BV; Volume: 11; Issue: 3 Linguagem: Inglês

10.1016/0006-291x(63)90340-1

1090-2104

A. Körner, A. J. Munro,

Chemical Synthesis and Analysis

Actinomycin inhibits the synthesis of RNA in bacteria and in mammalian cells in culture (Kirk, 1960; Reich, Franklin, Shatkin and Tatum, 1962; Tamaoki and Mueller, 1962; Harbers and Muller, 1962; Hurwitz, Furth, Malamy and Alexander, 1962; Goldberg, Rabinowitz and Reich, 1962). At least three types of RNA are concerned in protein biosynthesis so that inhibition of RNA synthesis should be reflected in inhibition of protein synthesis (cf. Kirk, 1960). Meritz (1963) has recently shown that actinomycin inhibits all RNA synthesis in rat liver and the evidence presented below indicates that actinomycin inhibits protein synthesis in rat liver.