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Bioactive Saponins from Swartzia s chomburgkii from the Suriname Rainforest

2000; American Chemical Society; Volume: 63; Issue: 11 Linguagem: Inglês

10.1021/np0000926

1520-6025

Maged S. Abdel‐Kader, Brian D. Bahler, Stan Malone, Marga C. M. Werkhoven, Jan H. Wisse, Kim M. Neddermann, Isia Bursuker, David G. I. Kingston,

Phytochemistry and Bioactive Compounds

Bioassay-guided fractionation of the MeOH extract of Swartzia schomburgkii using the engineered yeast strains 1138, 1140, and 1353 as the bioassay tool resulted in the isolation of five active (2, 4−7) and three inactive (1, 3, 8) saponins. Saponins 4 and 6 are previously unreported. The structures of all of the saponins were established based on 1D and 2D NMR spectral analysis, on acid and alkaline hydrolysis followed by TLC and GC−MS, and by comparison with literature data for known compounds. Three of the isolated compounds (4−6) showed weak cytotoxicity against the M-109 cell line.