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BIBTEX RIS

The structure and function of cartilage proteoglycans

2006; Volume: 12; Linguagem: Inglês

10.22203/ecm.v012a11

ISSN

1473-2262

Autores

PJ Roughley,

Tópico(s)

Glycosylation and Glycoproteins Research

Resumo

Cartilage contains a variety of proteoglycans that are essential for its normal function.These include aggrecan, decorin, biglycan, fibromodulin and lumican.Each proteoglycan serves several functions that are determined by both its core protein and its glycosaminoglycan chains.This review discusses the structure/function relationships of the cartilage proteoglycans, and the manner in which perturbations in proteoglycan structure or abundance can adversely affect tissue function.

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