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Antiviral Activity of Lactoferrin

1998; Springer Nature; Linguagem: Inglês

10.1007/978-1-4757-9068-9_23

2214-8019

Piera Valenti, М. Marchetti, Fabiana Superti, Maria Grazia Amendolia, Patrizia Puddu, Sandra Gessani, Paola Borghi, Filippo Belardelli, Giovanni Antonini, L Seganti,

Infant Nutrition and Health

In 1976, Matthews et al.19 reported the antiviral activity of milk proteins, underlining their possible clinical importance. Only recently, this effect has been ascribed mainly to lactoferrin (Lf). Lf was initially shown to exert a protective influence in mice infected with Friend leukemia virus15. Subsequently, a potent antiviral activity has been attributed to Lf, both in vitro towards cytomegalovirus (HCMV)9,7, herpes simplex virus (HSV)17, human immunodeficiency virus (HIV)7,29 and in vivo towards HSV-16 and HCMV25. Our groups provided evidence on the antiviral activity of Lf towards HSV-218, rotavirus28, and HIV22 infections (Table 1).