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Exercise-Induced Phospholipid Degradation in the Equine Skeletal Muscle and Erythrocytes.

1991; Japanese Society of Veterinary Science; Volume: 53; Issue: 6 Linguagem: Inglês

10.1292/jvms.53.1001

1347-7439

Naoaki Matsuki, Seiji Tamura, Kenichiro Ono, Toshihiro WATARI, Ryo Goitsuka, Akira YAMANOBE, Atsushi Hiraga, Katsuyoshi Kubo, Shigeyoshi Takagi, Atsuhiko Hasegawa, Naoyoshi Suzuki,

Adipose Tissue and Metabolism

To understand the pathogenesis of equine exercise-induced myopathies and hemolysis, changes of phospholipid peroxidation products in the equine middle gluteal muscle and erythrocytes following the high-speed treadmill exercise were studied. In the skeletal muscle, the peroxidized phosphatidylethanolamine (PE) were increased at 24 hours after the exercise. The malondialdehydes (MDAs) were also increased as the protein-bound MDAs following exercise. In the erythrocytes, the peroxidized PE were significantly decreased at 24 hours after the exercise. The protein-bound MDAs were significantly increased at 5 min after the exercise and returned to the base values at 24 hours after the exercise. These findings indicate that the PE is more susceptible to in vivo oxidative effects than the other phospholipid classes, and the accumulation of the protein-bound MDAs is considered to play some cytotoxic roles in the equine skeletal muscle and erythrocytes following exercise.