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NSAID-manufacturing plant effluent induces geno- and cytotoxicity in common carp ( Cyprinus carpio )

2015; Elsevier BV; Volume: 530-531; Linguagem: Inglês

10.1016/j.scitotenv.2015.05.088

1879-1026

Nely SanJuan‐Reyes, Leobardo Manuel Gómez‐Oliván, Marcela Galár-Martínez, Sandra García-Medina, Hariz Islas‐Flores, Edgar David González-González, Jesús Daniel Cardoso-Vera, Juan Manuel Jiménez-Vargas,

Aquaculture disease management and microbiota

The pharmaceutical industry generates wastewater discharges of varying characteristics and contaminant concentrations depending on the nature of the production process. The main chemicals present in these effluents are solvents, detergents, disinfectants – such as sodium hypochlorite (NaClO) – and pharmaceutical products, all of which are potentially ecotoxic. Therefore, this study aimed to evaluate the geno- and cytotoxicity induced in the common carp Cyprinus carpio by the effluent emanating from a nonsteroidal anti-inflammatory drug (NSAID)-manufacturing plant. Carp were exposed to the lowest observed adverse effect level (LOAEL, 0.1173%) for 12, 24, 48, 72 and 96 h, and biomarkers of genotoxicity (comet assay and micronucleus test) and cytotoxicity (caspase-3 activity and TUNEL assay) were evaluated. A significant increase with respect to the control group (p < 0.05) occurred with all biomarkers from 24 h on. Significant positive correlations were found between NSAID concentrations and biomarkers of geno- and cytotoxicity, as well as among geno- and cytotoxicity biomarkers. In conclusion, exposure to this industrial effluent induces geno- and cytotoxicity in blood of C. carpio.