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Sustained relief of oral aphthous ulcer pain from topical diclofenac in hyaluronan

1997; Elsevier BV; Volume: 84; Issue: 4 Linguagem: Inglês

10.1016/s1079-2104(97)90031-7

1528-395X

Mark A. Saxen, Walter T. Ambrosius, Al-Karim F Rehemtula, Alan Russell, George J. Eckert,

Nail Diseases and Treatments

Objectives. The purpose of this study was to test the hypothesis that topically applied 3% diclofenac in 2.5% hyaluronan reduces aphthous ulcer pain. Study design. A randomized, double-blind, single dose study of 60 healthy adults with aphthous ulcers in three treatment groups—3% diclofenac in 2.5% hyaluronan, 2.5% hyaluronan, 3% viscous lidocaine—was undertaken. Visual analogue scale pain scores were obtained before and after gel application and hourly, for up to 8 hours after gel application. Statistical analysis was performed with repeated measures ANOVA with square root transformation and Bonferroni correction. Results. A 48% overall reduction in pain (p < 0.01) was observed 10 minutes after gel application; however, no significant difference was found between the three topical agents. A 35% to 52% pain reduction (p < 0.01) was reported 2 to 6 hours after the application of diclofenac in hyaluronan, whereas hyaluronan gel alone and viscous lidocaine failed to produce significant VAS reductions. Conclusions. A dose of 3% diclofenac in 2.5% hyaluronan is an effective and novel treatment for this common, painful disorder.