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Comparative Test of the Effectiveness of Cefoperazone (T-1551) and Cefazolin (CEZ) on Respiratory Tract Infection by Double Blind Method (II)

1980; Volume: 54; Issue: 12 Linguagem: Inglês

10.11150/kansenshogakuzasshi1970.54.798

1884-569X

Keiichi Nakagawa, Kentaro Watanabe, Masaru KOYAMA, Norio Kihara, Tatsuo Suzuki, Akira Fukui, Yasumichi Kato, Akira Saitō, Masumi Tomizawa, Ichiro Nakayama, Yoshio KINOSHITA, Kiyofumi Ishikawa, Fumio Nagahama, Takehito NAKABAYASHI, Shinya YASUDA, Tetsuji KOROKU, Takahisa Saito, Kazunori HARADA, Hiroshi Kon, Takashi Mikami, Nobuo Watanabe, Yasumasa Yokota, T Kirisawa, Akira NAKASATO, Akira Sasaki, Masataka Ito, Ryuji Sato, Kazuo Takebe, Yoshihiro KUMASAKA, Hisashi Nakahata, S Kosaka, Mitsuo Nakamura, Kenichi Imamura, K Machida, Kazuo SASAKI, Katsuhiro OKAMOTO, Shuichiro Yoshida, Hiroyasu Kawabe, Mitsuaki Yoshioka, Shokou NARITA, Masahiro TSUTSUI, Tamotsu Takishima, Sumio Arai, Kazuki Konishi, T Taima, Nobuo Sato, Hajime TAKEDA, Masatoshi NIWAYAMA, Fusanosuke YAMASAKU, Yasutoshi Suzuki, Osamu Sekine, Yoshimaru Usuda, Nobuki Aoki, Yasuko Yuasa, Izumi Hayashi, Masataka Katsu, Mieko KAWAI, T Aoyagi, Noboru Yanai, Iwao Takanami, Masashi Mouri, O Kunii, Kazufuto FUKAYA, Yasushi Ueda, Atsushi Saitô, Jingoro Shimada, Masahisa OOMORI, Kooya SHIBA, Takehisa Yamaji, Hironobu Ihara, Toshio Hōjō, Tadashi Miyahara, Hiroichi Tanimoto, Akio Tachibana, Koichiro NAKADA, M Suzuki, Kaoru Shimada, Takashi Inamatsu, Kyoko URAYAMA, Keimei Mashimo, Sumio YAMAOKA, Junzaburo Kabe, O Kitamoto, Hiroyuki Kobayashi, Hideo IKEMOTO, Ikko WATANABE, Terumi Takahashi, Touji ODAGIRI, Ippei FUJIMORI, Yasuo MASTUOKA, Yoshio Kobayashi, Kojiro Sekita, Kenji Mitsui, Kokichi Fukushima, Akira Ito, Hideyuki Hasegawa, Koichi YAMANAKA, Kunihiko SINDO, Ryuichiro YAMASAKI, Makio KURIHARA, Takashi Suyama, Raiji YAMAMOTO, Yukihiko Obigane, Shizuo Abe, T Takigami, Kaoru OYAMA, Naoki Suzuki, Masao Kurosaki, Mitsuru Hayase, Nobuo OOYA, Toshiyuki YAMAMOTO, Masahito Kato, Hirohiko Nagasaka, Kozo Mori, Saburo Kitaura, Kunio Nanjo, Joichi Kato, Nobuo Maekawa, Michiyasu NAKANISHI, Nobuo Inaba, Yoshiro Oda, Kenzo Shiota, Fumio Miki, Akira Ōkubo, Yuruko OKAMOTO, Fumihiko Uba, Yoshihiro Ueda, Keigo MAEHARA, Rinzō Soejima, Toshiharu Matsushima, Yoshihiko Tano, Yoshito Niki, Susumu Yagi, Hironori Hara, Kyosei SODA, Naomi Kimura, Takanobu Matsumoto, Hiroshi SEWAKE, Mitsue NISHIMURA, Mikio HAYAKAWA, Hiromichi KUNIKI, Osamu Kurimura, Kazue Sadamoto, Hideo Sasaki, Eiro Tsubura, Yoshihiro TAKISHITA, Toshihiro Goto, Yoshiro Sawae, Kaoru Okada, Tsuneo Ishibashi, M Takamoto, Fumihiko Maeda, Tetsuo FUJIKI, Minoru Yoshida, Hitoshi Nagano, Shinichi Matsuo, Kohei Hara, Masao Nakatomi, Masaru Nasu, Atsushi Saitô, Tsuneo Tsutsumi, Yoshiteru SHIGENO, Masaki Hirota, Keizo Matsumoto, Harumi Shishido, Hisao Kimura, Kouichi Yokoyama, Masato Hayashi, Chiyohiko Shindo, H Tokuomi, Yasutsugu Fukuda, Katsumasa Tokunaga, Kiyoshi Shima, Teruya ICHIKI,

Phenothiazines and Benzothiazines Synthesis and Activities

Comparative test by double blind method were conducted by administering 2 g of CPZ and 4 g of CEZ as a control per day for comparing the actions of both the medicines in order to ascertain the efficacy and safety of CPZ against respiratory tract infection.Clinical examination indicated the effectiveness of CPZ in 75.2% of the cases, while CEZ proved effective in 56.5% of the cases, and showed that CPZ was significantly advantageous over CEZ.CPZ showed a signifficant advantage over CEZ against the individual diseases. In the cases involving bacterial pneumonia, CPZ was effective in 86.2% of the cases, while CEZ was effective in 64.4% and in the cases involving chronic respiratory tract infection, CPZ showed an efficacy of 63.6%, while CEZ was effective in 40.0% of the cases.As regards the bacteriological effects of the medicines, CPZ showed a significantly high efficacy in Gram-negative bacteria. CPZ was effective in 70.6% of the cases, while CEZ was effective in 54.5%, even though Pseudomonas, Enterobacter and H. influenzae having no or very little sensitivity to CEZ were excluded from consideration.No significant difference was observed between the two medicines in the manifestation of any side effect or abnormality in laboratory findings. All of such side effects and abnormalities that were observed were merely of the type usually observed with medicines composed of β-lactam.The utility of CPZ was significantly superior to that of CEZ.In view of the foregoing results, CPZ would be sufficient for effective treatment of respiratory tract infection.