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TOLERABILITY OF IBUPROFEN, ASPIRIN AND PARACETAMOL FOR THE TREATMENT OF COLD AND FLU SYMPTOMS AND SORE THROAT PAIN

2002; Wiley; Volume: 56; Issue: 10 Linguagem: Inglês

10.1111/j.1742-1241.2002.tb11366.x

1742-1241

Nicholas Moore, J-M. Le Parc, Éric Van Ganse, Ronald Wall, H Schneid, R. Cairns,

Inflammatory mediators and NSAID effects

This double-blind randomised study compared the tolerability of ibuprofen (up to 1.2 g daily), aspirin and paracetamol (both up to 3 g daily) for up to seven days, in patients with mild to moderate pain resulting from cold/flu symptoms or sore throat (CF/ST) (n = 2,815). The main outcome was the rate of significant adverse events (SGAE). Rates of SGAE for ibuprofen, aspirin and paracetamol were respectively 12.0%, 15.7% and 12.3%. Ibuprofen was significantly better tolerated than aspirin (p = 0.02) and had comparable tolerability with paracetamol. The latter was also true for total digestive system events and for abdominal pain and dyspepsia. In conclusion, in patients with CF/ST, ibuprofen used at over-the-counter doses is as well tolerated as paracetamol and much better tolerated than aspirin.