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Disseminated intravascular coagulation in newborn infants

1982; Elsevier BV; Volume: 174; Issue: 1-2 Linguagem: Inglês

10.1016/s0344-0338(82)80033-2

1618-0631

Masashi Dairaku, Kenji Sueishi, Kentaro Tanaka,

Blood disorders and treatments

Two hundred and one consecutive autopsies of the newborns were clinicopathologically analyzed for the prevalence of disseminated intravascular coagulation (DIC) and its significance as a cause of death. DIC confirmed histopathologically by the presence of many microthrombi in three or more organs was accompanied in 24 cases (11.9%) with various underlying diseases. Factors predisposing to DIC in the newborns included hyaline membrane disease (29.2%), maternal complications (70.8%) and infections (16.7%). Microthrombi were found in the lungs of all the cases with DIC, but were rare in the kidneys, especially in glomeruli. Visceral lesions of DIC were characterized by a wide diversity of histopathological features including ischemic lesions.