Portal de Periódicos da CAPES

Obesity in Pulmonary Arterial Hypertension. The Pulmonary Hypertension Association Registry

2020; American Thoracic Society; Volume: 18; Issue: 2 Linguagem: Inglês

10.1513/annalsats.202006-612oc

2329-6933

Jeff Min, Rui Feng, David B. Badesch, Erika B. Rosenzweig, Charles D. Burger, Murali M. Chakinala, Teresa De Marco, Jeremy Feldman, Anna R. Hemnes, Evelyn M. Horn, Matthew R. Lammi, Stephen C. Mathai, John W. McConnell, Kenneth W. Presberg, Jeffrey C. Robinson, Jeffrey S. Sager, Oksana A. Shlobin, Marc A. Simon, Thenappan Thenappan, Corey E. Ventetuolo, Nadine Al‐Naamani, Roblee P. Allen, Sonja Bartolome, Raymond L. Benza, Todd Bull, Linda Cadaret, Michael Eggert, Jean Elwing, Jeffrey R. Fineman, Raymond Foley, H. James Ford, Robert P. Frantz, Russel Hirsch, James Grinnan, D. Dunbar Ivy, Steven M. Kawut, Jamie L.W. Kennedy, James R. Klinger, Peter J. Leary, Sula Mazimba, Gautam Ramani, Amresh Raina, James Runo, J. Swisher, John Ryan, Nidhy P. Varghese, R. James White, Timothy Williamson, Delphine Yung, Roham T. Zamanian, Dianne Zwicke,

Vascular Anomalies and Treatments

Obesity is associated with pulmonary arterial hypertension (PAH), but its impact on outcomes such as health-related quality of life (HRQoL), hospitalizations and survival is not well understood. To assess the effect of obesity on health-related quality of life (HRQoL), hospitalizations and survival in patients with PAH. We performed a cohort study of adults with PAH from the Pulmonary Hypertension Association Registry, a prospective multicenter registry. Multivariate linear mixed effects regression was used to examine the relationship between weight categories and HRQoL using the Short Form-12 (SF-12) and emPHasis-10 (e10). We used multivariable negative binomial regression to estimate hospitalization incidence rate ratios (IRRs) and Cox regression to estimate hazard ratios (HRs) for transplant-free survival by weight status. 767 subjects were included: mean age of 57 years, 74% female, 33% overweight and 40% obese, with median follow-up duration of 527 days. Overweight and obese patients had higher baseline e10 scores (worse HRQoL), which persisted over time (p<0.001). The overweight and obese have a trend towards increased incidence of hospitalizations compared to normal weight (IRR 1.34, 95% confidence interval (95%CI) 0.94-1.92 and 1.33, 95%CI 0.93-1.89, respectively). Overweight and obese patients had lower risk of transplant or death as compared to normal weight patients (HR 0.45, 95%CI 0.25-0.80 and 0.39, 95%CI 0.22-0.70, respectively). In a large multicenter, prospective cohort of PAH, overweight and obese patients had worse disease-specific HRQoL despite better transplant-free survival compared to normal weight patients. Future interventions should address the specific needs of these patients.