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The effects of the silence on south African children and adolescents against a global alert on the newly identified coronavirus variant: Omicron

2021; Elsevier BV; Volume: 65; Linguagem: Inglês

10.1016/j.pedn.2021.11.032

1532-8449

Danielly Gonçalves Sombra Lima, Thânia Maria Rodrigues Figueiredo, Yara Talita Gomes Pereira, Maria Auxiliadora Ferreira Brito Almino, Liliany Medeiros Pereira, Hildson Leandro de Menezes, Jaime Emanuel Brito Araújo, Jucier Gonçalves Júnior, Nélio Barreto Vieira, Sionara Melo Figueiredo de Carvalho, Sávio Samuel Feitosa Machado, Cícera Janielly de Matos Cassiano, Barbara Silveira Dionizio, Raul Cesár Fortaleza Pinheiro, Pedro Walisson Gomes Feitosa, Francisco Helder Pereira Filho, Nádia Nara Rolim Lima, Modesto Leite Rolim Neto,

SARS-CoV-2 and COVID-19 Research

•Children and adolescents in South Africa, signal a global alert to Omicron.•Children aged 10 to 19 years accounted for 9.2% of all COVID-19 cases reported since the start of the pandemic. The discovery of a new variant of the coronavirus potentially more communicable by South African health authorities has sparked concern for poor, marginalized, and anonymous children and adolescents in countries with a strong tendency towards vulnerability and social risk (Brasil et al., 2021Brasil A.A.G.M. Silva K.V.C.C. Gonçalves-Junior J. Alves R.N.P. Lima N.N.R. Cassiano C.J.M. Rolim-Neto M.L.R.N. Social inequalities and extreme vulnerability of children and adolescents impacted by the covid-19 pandemic.The Lancet Regional Health – Americas. 2021; 19: 100103https://doi.org/10.1016/j.lana.2021.100103Google Scholar). In this context, the World Health Organization -WHO, 2021World Health Organization -WHO Classification of omicron (B.1.1.529): SARS-CoV-2 variant of concern.https://www.who.int/news/item/26-11-2021-classification-of-omicron-(b.1.1.529)-sars-cov-2-variant-of-concernDate: 2021Google Scholar designated the newly identified variant of the coronavirus, B.1.1.529, as Omicron. In addition to South Africa, the newly identified variant has been detected in Botswana, Hong Kong, Belgium, and recently the UK. As children and adolescents in South Africa, due to the precarious conditions in which they live and the health crisis that surround them, signal a global alert, as they feel more quickly, deeply, and prolonged the effects that the variant can cause, resulting in immune evasion. As the variant is spreading very fast and acting differently, it is proving to be more contagious than even the Delta (Centre for Disease Control – CDC, 2021Centre for Disease Control – CDC COVID-19 variants.http://www.bccdc.ca/health-info/diseases-conditions/covid-19/about-covid-19/variantsDate: 2021Google Scholar) variant. In this sense, this variant is considered as worrying in the spaces of conflicts and its repercussions on the financial difficulties of families, as it expresses a problem of multidimensional poverty, where the position of children and adolescents face levels of responses, reactions, effects, confrontations in the systems and social protection and health programs (Genomic surveillance of SARS-CoV-2 in Belgium, 2021Genomic surveillance of SARS-CoV-2 in Belgium Report of the national reference laboratory (UZ Leuven & KU Leuven). (report 2021_56).https://assets.uzleuven.be/files/2021-11/genomic_surveillance_update_211126.pdfDate: 2021Google Scholar). Therefore, there is a concern in children and youth spaces that this variant may have higher potential than previous variants. The new version of the virus was detected on November 22 in Gauteng province, whose capital is Johannesburg. The new variant carries a series of mutations that have already been seen but not matched. Seeing them together is what elevates it to being a variant under surveillance. Not so much because there is data that it is actually more transmissible or puts the immune system at risk, but due to what it may have the potential to do so (El El Pais, 2021El Pais Nova variante do coronavírus detectada na África do sul acumula mais de 30 mutações.https://brasil.elpais.com/ciencia/2021-11-26/nova-variante-do-coronavirus-detectada-na-africa-do-sul-acumula-mais-de-30-mutacoes.htmlDate: 2021Google Scholar). The National Institute of Infectious Diseases of South Africa said, on Friday, that no unusual symptoms related to cases of the variant had been detected. What is happening now is inevitable, it is the result of the world's failure to vaccinate equitably, urgently and quickly. It is the result of the accumulation [of vaccines] by the world's high-income countries, and quite frankly, it is unacceptable (African African Union, 2021African Union 82nd weekly press briefing on the coronavirus disease outbreak.https://au.int/en/videos/20211111/81th-weekly-press-briefing-coronavirus-disease-outbreakDate: 2021Google Scholar). Children and adolescents may complain mainly of body aches and tiredness, extreme tiredness (BBC BBC News, 2021BBC News Covid: South Africa 'punished' for detecting new omicron variant.https://www.bbc.com/news/world-59442129Date: 2021Google Scholar). The mutation profile is worrying, but now we need to understand the meaning of this variant and what it means for the health of children and adolescents (Callaway, 2021Callaway E. Heavily mutated Omicron variant puts scientists on alert. Nature.Nature. 2021; 600: 2https://www.nature.com/articles/d41586-021-03552-w/Crossref Scopus (156) Google Scholar). Even as the South African variant becomes more widespread and dominant, it is important that the mRNA (Pfizer-BioNTech and Modern) and adenovirus vector (Oxford-Astrazeneca and Russian Sputnik V) vaccines can be modified to be more suitable and effective against this variant in a few months. The 'South African variant' carries a mutation in the spike protein called E484K, which is not present in the 'UK strain'. The E484K mutation has been shown to reduce antibody recognition (Aljazeera, 2021Aljazeera What do we know about the new COVID strain found in South Africa?.https://www.aljazeera.com/news/2021/11/26/what-do-we-know-about-the-new-south-africa-covid-variantDate: 2021Google Scholar; Centre for Disease Control – CDC, 2021Centre for Disease Control – CDC COVID-19 variants.http://www.bccdc.ca/health-info/diseases-conditions/covid-19/about-covid-19/variantsDate: 2021Google Scholar). We urgently need a properly informed debate. The global appeal is in terms of vaccinations in the African region, particularly that vaccines are distributed there because, as we know, the variants do not stay in one country. Before detecting the new variant, authorities predicted a fourth wave to hit South Africa. It is paramount to reflect that South Africa has the highest number of pandemics in Africa, with approximately 2.95 million cases, of which 89,657 were fatal (Aljazeera, 2021Aljazeera What do we know about the new COVID strain found in South Africa?.https://www.aljazeera.com/news/2021/11/26/what-do-we-know-about-the-new-south-africa-covid-variantDate: 2021Google Scholar). The National Institute of Communicable Diseases of South Africa extended COVID-19 vaccination to adolescents aged 12 to 17 years. For the week of 10 to 16 October 2021, this age group accounted for 14.7% of newly reported cases of COVID-19, compared to a peak of about 20% midway through the third resurgence. In the middle of October, children aged 10 to 19 years accounted for 9.2% of all COVID-19 cases reported since the start of the pandemic. It is particularly important for adolescents with underlying illnesses - such as diabetes, cancer, HIV, and obesity 10. In this context, adolescents with these underlying illnesses are at greater risk of death from COVID-19 compared to adolescents without underlying illnesses. These underlying conditions accounted for 22% of adolescents admitted to the hospital with COVID-19, but 60% of those who died from it (African Union, 2021African Union 82nd weekly press briefing on the coronavirus disease outbreak.https://au.int/en/videos/20211111/81th-weekly-press-briefing-coronavirus-disease-outbreakDate: 2021Google Scholar; Aljazeera, 2021Aljazeera What do we know about the new COVID strain found in South Africa?.https://www.aljazeera.com/news/2021/11/26/what-do-we-know-about-the-new-south-africa-covid-variantDate: 2021Google Scholar; National Institute for Communicable Diseases -NICD, 2021National Institute for Communicable Diseases -NICD COVID-19: Unpacking South Africa's plan to vaccinate adolescentes.https://www.nicd.ac.za/covid-19-unpacking-south-africas-plan-to-vaccinate-adolescents/Date: 2021Google Scholar). We must provide visibility to these children and adolescents who are victims of different experiences, located at the intersection of a series of markers that produce inequality and asymmetry in the health/disease relationships. The structural injustice facing this group raises an important place in the production of scientific knowledge. What would be the real truth? School of Medicine Estácio/FMJ from Juazeiro do Norte (Productivity Scholarship Program) and Brazilian National Council for Scientific and Technological Development (CNPq) – institution linked to the Brazilian Department of Science, Technology and Innovation to encourage research in Brazil.