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Transmission from vaccinated individuals in a large SARS-CoV-2 Delta variant outbreak

2021; Cell Press; Volume: 185; Issue: 3 Linguagem: Inglês

10.1016/j.cell.2021.12.027

1097-4172

Katherine J. Siddle, Lydia A. Krasilnikova, Gage K. Moreno, S. F. Schaffner, Johanna Vostok, Nicholas FitzGerald, Jacob E. Lemieux, Nikolaos Barkas, Christine Loreth, Ivan Specht, Christopher H. Tomkins-Tinch, Jillian S. Paull, Beau Schaeffer, Bradford P. Taylor, Bryn C. Loftness, Hillary Johnson, Petra Schubert, Hanna Shephard, Matthew Doucette, Timelia Fink, Andrew S. Lang, Stephanie Baez, John Beauchamp, Scott Hennigan, Erika Buzby, Stephanie Ash, Jessica Brown, Selina Clancy, Seana Cofsky, Luc Gagne, Joshua C. Hall, Rachel Harrington, Gabrielle Gionet, Katherine C. DeRuff, Megan E. Vodzak, Gordon Adams, Sabrina T. Dobbins, Sarah D. Slack, Steven K. Reilly, Lisa M. Anderson, Michelle Cipicchio, Matthew DeFelice, Jonna Grimsby, Scott E. Anderson, Brendan Blumenstiel, James C. Meldrim, Heather M. Rooke, Gina Vicente, Natasha L. Smith, Katelyn S. Messer, Faye L. Reagan, Zoe M. Mandese, Matthew Lee, Marianne C. Ray, Marissa Fisher, Maesha A. Ulcena, Corey M. Nolet, Sean English, Katie Larkin, Kyle Vernest, Sushma Chaluvadi, Deirdre Arvidson, Maurice Melchiono, Theresa Covell, Vaira Harik, Taylor Brock-Fisher, Molly Dunn, Amanda Kearns, William P. Hanage, C. Bernard, Anthony Philippakis, Niall J. Lennon, Stacey Gabriel, Glen R. Gallagher, Sandra Smole, Lawrence C. Madoff, Catherine Brown, Daniel J. Park, Bronwyn MacInnis, Pardis C. Sabeti,

SARS-CoV-2 detection and testing

An outbreak of over 1,000 COVID-19 cases in Provincetown, Massachusetts (MA), in July 2021-the first large outbreak mostly in vaccinated individuals in the US-prompted a comprehensive public health response, motivating changes to national masking recommendations and raising questions about infection and transmission among vaccinated individuals. To address these questions, we combined viral genomic and epidemiological data from 467 individuals, including 40% of outbreak-associated cases. The Delta variant accounted for 99% of cases in this dataset; it was introduced from at least 40 sources, but 83% of cases derived from a single source, likely through transmission across multiple settings over a short time rather than a single event. Genomic and epidemiological data supported multiple transmissions of Delta from and between fully vaccinated individuals. However, despite its magnitude, the outbreak had limited onward impact in MA and the US overall, likely due to high vaccination rates and a robust public health response.