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sTREM-1 Predicts Disease Severity and Mortality in COVID-19 Patients: Involvement of Peripheral Blood Leukocytes and MMP-8 Activity

2021; Multidisciplinary Digital Publishing Institute; Volume: 13; Issue: 12 Linguagem: Inglês

10.3390/v13122521

ISSN

1999-4915

Autores

Pedro V. da Silva‐Neto, Jonatan C. S. de Carvalho, Vinícius E. Pimentel, Malena M. Pérez, Diana Mota Toro, Thais Fernanda de Campos Fraga‐Silva, Carlos Alessandro Fuzo, Camilla N. S. Oliveira, Lílian Cataldi Rodrigues, Jamille Guedes Malta Argolo, Ingryd Carmona‐Garcia, Nicola T. Neto, Camila Oliveira Silva Souza, Talita Morais Fernandes, Víctor Alexandre Félix Bastos, Augusto M. Degiovani, Leticia F. Constant, Fátima M. Ostini, Marley Ribeiro Feitosa, Rogério Serafim Parra, Fernando Crivelenti Vilar, Gilberto Gambero Gaspar, José Joaquim Ribeiro da Rocha, Omar Féres, Fabiani Gai Frantz, Raquel F. Gerlach, Sandra Regina Maruyama, Elisa Maria de Sousa Russo, Angelina Lettiere-Viana, Ana Paula Fernandes, Isabel Kinney Ferreira de Miranda Santos, Vânia Luiza Deperon Bonato, Antônio Luiz Boechat, Adriana Malheiro, Ruxana T. Sadikot, Marcelo Dias‐Baruffi, Cristina Ribeiro de Barros Cardoso, Lúcia Helena Faccioli, Carlos A. Sorgi,

Tópico(s)

Inflammation biomarkers and pathways

Resumo

Uncontrolled inflammatory responses play a critical role in coronavirus disease (COVID-19). In this context, because the triggering-receptor expressed on myeloid cells-1 (TREM-1) is considered an intrinsic amplifier of inflammatory signals, this study investigated the role of soluble TREM-1 (sTREM-1) as a biomarker of the severity and mortality of COVID-19. Based on their clinical scores, we enrolled COVID-19 positive patients (

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