Produção Nacional
Revisado por pares
The role of spray-drying atmosphere on fridericia chica (bonpl.) L.G. Lohmann standardized extract production for wound healing activity
2021; Taylor & Francis; Volume: 36; Issue: 18 Linguagem: Inglês
10.1080/14786419.2021.2012773
ISSN1478-6427
AutoresIlza Maria de Oliveira Sousa, Gerardo Álvarez‐Rivera, Diana Pinto, Núbia de Cássia Almeida Queiroz, Verónica Bastos, Lúcia E.O. Braga, Josman Dantas Palmeira, Helena Amaral, Helena Ferreira, Helena Oliveira, Fernando Gonçalves, Ana Lúcia Tasca Góis Ruiz, Elena Ibáñez, M. Beatriz P.P. Oliveira, Mary Ann Foglio,
Tópico(s)Phytochemistry Medicinal Plant Applications
ResumoFridericia chica (Bonpl.) L.G. Lohmann (synonym Arrabidaea chica Verlot) is widely used in Brazilian folk medicine. Considering overcoming pitfalls of scaling up production of plant extracts, herein the effects of N2 atmosphere for extract spray-drying process is reported. Samples were monitored by in vitro antioxidant activity and microbiological evaluation. The drying atmosphere influenced 3-deoxyanthocyanines content when using air as atomizing gas, decreasing carajurin (37.5%) content with concomitant increase in luteolin yield (24.1%). Both drying processes preserved the pharmacological activity. In the cell migration test with HaCaT cells, the extract dried under air flow (5 μg/mL) promoted wound closure by 78% (12 hours) whereas the extract dried using N2 flow promoted 49% (12 hours), with 98% closure (12 hours) for the positive control. The antimicrobial evaluation for Staphylococcus aureus did not differ within drying atmospheres, with MIC (minimum inhibitory concentration) at 0.39 mg/mL. Therefore, the drying process reported herein did not interfere with the biological activity's outcome.
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