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How do sphingolipids play a role in epigenetic mechanisms and gene expression?
2021; Future Medicine; Volume: 14; Issue: 5 Linguagem: Inglês
10.2217/epi-2021-0425
ISSN1750-1911
AutoresGabriel Silva, Fernanda Borchers Coeli‐Lacchini, Andréia Machado Leopoldino,
Tópico(s)Autophagy in Disease and Therapy
ResumoEpigenomicsVol. 14, No. 5 EditorialHow do sphingolipids play a role in epigenetic mechanisms and gene expression?Gabriel da Silva, Fernanda B Coeli-Lacchini & Andréia Machado LeopoldinoGabriel da Silva https://orcid.org/0000-0002-5660-9769Depto de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil., Fernanda B Coeli-Lacchini https://orcid.org/0000-0001-6568-7497Depto de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil. & Andréia Machado Leopoldino *Author for correspondence: E-mail Address: andreiaml@usp.brhttps://orcid.org/0000-0002-8313-4754Depto de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.Published Online:15 Dec 2021https://doi.org/10.2217/epi-2021-0425AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: ceramidedihydrosphingosineDNA methylationepigeneticsgene expressionHDAChistone acetylationnoncoding RNAS1PsphingolipidsPapers of special note have been highlighted as: • of interest; •• of considerable interestReferences1. 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Body mass index in multiple sclerosis modulates ceramide-induced DNA methylation and disease course. EBioMedicine 43, 392–410 (2019). • There are data to support ceramide as a potential regulator or player in DNA methylation potentially associated with gene expression.Crossref, Medline, Google ScholarFiguresReferencesRelatedDetailsCited ByEnriched dietary saturated fatty acids induce trained immunity via ceramide production that enhances severity of endotoxemia and clearance of infection20 October 2022 | eLife, Vol. 11The potential consequences of bidirectional promoter methylation on GLA andHNRNPH2 expression in Fabry disease phenotypes in a family of patients carrying a GLA deletion variant24 June 2022 | Biomedical Reports, Vol. 17, No. 2 Vol. 14, No. 5 Follow us on social media for the latest updates Metrics Downloaded 62 times History Received 31 October 2021 Accepted 15 November 2021 Published online 15 December 2021 Published in print March 2022 Information© 2022 Future Medicine LtdKeywordsceramidedihydrosphingosineDNA methylationepigeneticsgene expressionHDAChistone acetylationnoncoding RNAS1PsphingolipidsFinancial & competing interests disclosureThe authors are supported by the following grants: Conselho Nacional de Desenvolvimento Científico e Tecnológico (301560/2018-8); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES/001); and Fundação de Amparo à Pesquisa do Estado de São Paulo (2016/19103-2; 2018/17480-9). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download
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